Multicompartment hard capsule with control release properties

Details Multicompartment hard capsule with control release properties Multicompartment hard capsule with control release properties

1995-11-20

1997-09-30

Levy, Neil S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424452, 424453, 424454, 424455, 424456, 424408, A61K 952

Patent

active

056723598

ABSTRACT:
The present invention relates to a hard capsule made from a material such as gelatin, starch or a hydrophilic polymer. The capsule of the present invention is formulated into a delivery system which incorporates pharmacologically active components in three or more distinct compartments. When three compartments are utilized in the capsule, the outer compartment incorporates a drug and excipients into a layer which coats the outer part of the capsule. This layer represents the rapid release portion of the delivery system. The intermediate compartment comprises a powder formulation comprised of a drug and excipients which represents the intermediary speed release portion of the delivery system. The innermost compartment incorporates the active ingredient or ingredients in a multiparticulate form, such as small pellets, and represents the slow release component of the delivery system.

REFERENCES:
patent: 2451022 (1948-10-01), Domrmann
patent: 3122475 (1964-02-01), Schaeppi
patent: 3197369 (1965-07-01), Widmann et al.
patent: 3415249 (1968-12-01), Sperti
patent: 3814809 (1974-06-01), Gordon
patent: 4707362 (1987-11-01), Nuwayser
patent: 4828840 (1989-05-01), Sakamoto et al.
patent: 4880830 (1989-11-01), Rhodes
patent: 4994279 (1991-02-01), Aoki et al.
patent: 5023088 (1991-06-01), Wong et al.
patent: 5156849 (1992-10-01), Byrne et al.
patent: 5219572 (1993-06-01), Sivarmakrishnan
patent: 5262173 (1993-11-01), Sheth et al.
patent: 5271945 (1993-12-01), Yoshioka et al.
patent: 5314697 (1994-05-01), Kwan et al.
patent: 5320853 (1994-06-01), Noda et al.
patent: 5472708 (1995-12-01), Chen
Merck Index, Abstract 6101, Miconazole, p. 972.
Merck Index, Abstract 139, Acyclovir, p. 24.
Porter, S.C. "Coating of Pharmaceutical Dosage Forms", Remington's Pharmaceutical Sciences, 18th Ed.(1990) published by Mack Publishing Co., Easton, PA, pp.1666-1675.
Kraeling, M.E.K. and Ritschel, W.A. "Development of a Colonic Release Capsule Dosage From and the Absorption of Insulin", Meth. Find. Exp. Clin. Pharmacol., vol. 14, No. 3, (1992) pp. 199-209.

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