Chemistry of inorganic compounds – Treating mixture to obtain metal containing compound – Radioactive metal
Reexamination Certificate
2006-08-08
2006-08-08
Nguyen, Ngoc-Yen (Department: 1754)
Chemistry of inorganic compounds
Treating mixture to obtain metal containing compound
Radioactive metal
C423S003000, C423S006000, C423S007000, C423S011000, C423S249000, C423SDIG018, C210S682000
Reexamination Certificate
active
07087206
ABSTRACT:
A multicolumn selectivity inversion generator separation method has been developed in which actinium ions, a desired daughter radionuclide, are selectively extracted from a solution of the thorium parent and daughter radionuclides by a primary separation column, stripped, and passed through a second guard column that retains any parent or other daughter interferents, while the desired daughter actinium ions and radium ions elute. This separation method minimizes the effects of radiation damage to the separation material and permits the reliable production of radionuclides of high chemical and radionuclidic purity for use in diagnostic or therapeutic nuclear medicine.
REFERENCES:
patent: 4265862 (1981-05-01), White et al.
patent: 4548790 (1985-10-01), Horwitz et al.
patent: 4574072 (1986-03-01), Horwitz et al.
patent: 4835107 (1989-05-01), Horwitz et al.
patent: 5246691 (1993-09-01), Geerlings et al.
patent: 5641471 (1997-06-01), Geerlings
patent: 5854968 (1998-12-01), Horwitz et al.
patent: 5885465 (1999-03-01), Bray et al.
patent: 6127527 (2000-10-01), Geerlings
patent: 6403771 (2002-06-01), Geerlings
patent: 6667024 (2003-12-01), Goldenberg et al.
patent: 6770195 (2004-08-01), Young et al.
patent: 6787042 (2004-09-01), Bond et al.
patent: 2003/0127395 (2003-07-01), Bond et al.
patent: 2002001007 (2002-01-01), None
patent: 2002243890 (2002-08-01), None
Adelstein et al. Eds.,Isotopes for Medicine and the Life Sciences, National Academy Press (Washington, D.C.: 1995), pp. i-x and 1-8.
Bond et al., “Nuclear Separations for Radiopharmacy: The Need for Improved Separations to Meet With Future Research and Clinical Demands”,Ind. Eng. Chem. Res.(2000) 36:3130-3134.
Choppin et al.,Nuclear Chemistry: Theory and Applications, Pergamon Press (Oxford: 1980), p. 310-312.
Hassfjell et al., “The Development of the α-Particle Emitting Radionuclides212Bi and213Bi, and Their Decay Related Radionuclides, for Therapeutic Applications”,Chem. Rev.(2001) 101:2019-2036.
Horwitz et al., “Separation and Preconcentration of Strontium for Biological, Environmental, and Nuclear Waste Samples by Extraction Chromatography Using a Crown Ether”,Analytical Chemistry(1991) 63:522-525.
Imam, “Advancements in Cancer Therapy with Alpha-Emitters: A Review”,Int. J. Radiation Oncology Biol. Phys.(2001) 51(1):271-278.
Lambrecht et al., “Radionuclide Generators”,Radiochimica Acta(1997) 77:103-123.
McDevitt et al., “Tumor Therapy with Targeted Atomic Nanogenerators”,Science(Nov. 2001) 294:1537-1540.
Mirzadeh, “Generator-Produced Alpha-Emitters”,Appl. Radiat. Isot.(1998) 49(4):345-349.
Sasaki et al., “The Novel Extractants, Diglycolamides, for the Extraction of the Lanthanides and Actinides in HNO3-n-Dodecane System”,Solvent Extraction and Ion Exchange(2001) 19(1):91-103.
Sasaki et al., “Extraction of Actinides (III), (IV), (V), (VI), and Lanthanides (III) by Structurally Tailored Diamides”,Solvent Extraction and Ion Exchange(2002) 20(1):21-34.
Tachimori, “A New Extractant for Actinide Separation Developed: Separation and Recovery of All Actinides with High Efficiency”, www.jaeri.go.up/English/press/00808, (Aug. 8, 2000).
Wagner et al., “Expert Panel: Forecast Future Demand for Medical Isotopes”, Department of Energy, Office of Nuclear Energy, Science, and Technology 1999.
Whitlock et al., “Radionuclide Therapy for the Treatment of Microscopic Ovarian Carcinoma: An Overview”,Ind. Eng. Chem. Res.(2000) 39:3135-3139.
Bond Andrew H.
Horwitz E. Philip
McAlister Daniel R.
Nguyen Ngoc-Yen
PG Research Foundation
Welsh & Katz Ltd.
LandOfFree
Multicolumn selectivity inversion generator for production... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Multicolumn selectivity inversion generator for production..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multicolumn selectivity inversion generator for production... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3637282