Measuring and testing – Gas analysis – Gas chromatography
Patent
1980-12-16
1982-10-12
Kreitman, Stephen A.
Measuring and testing
Gas analysis
Gas chromatography
73 611C, G01N 3108
Patent
active
043532420
ABSTRACT:
A method and apparatus for resolving overlapped chromatographic peaks or other overlapped data obtained from operation of a differential migration apparatus used to analyze a substance whose composition is to be determined. The invention involves using a second analytical apparatus, such as a spectrometer, to supplement the data obtained from the basic differential migration apparatus. A multi-channel detector is used to monitor and record the various sets of data obtained from these apparatus. Data corresponding to regions of overlap identified by the apparatus are assembled in a measured data set. An estimated data set is then compiled describing the estimated migrational time behavior of each of a plurality of compounds present within the overlapped region. An identifying data set is then calculated based upon the estimated data set and the measured data set. This identifying data set contains unique identifying data, such as spectral data, corresponding to each compound present within the overlapped region. Errors in the identifying data set are minimized through an iterative process that modifies the estimated data set with each iteration. When the error is reduced to an acceptable level, the identifying data set serves to finally determine the number and identity of the compounds present within the region of overlap, i.e., resolve the overlapped peak, matrix techniques are advantageously used to handle and manipulate the large amount of data that is measured and generated. A computer may also advantageously be used to facilitate the speed and accuracy with which the matrices may be manipulated.
REFERENCES:
patent: 3365931 (1968-01-01), MacRitchie et al.
patent: 3566674 (1971-03-01), Talroze et al.
patent: 3726127 (1973-04-01), Putnam et al.
patent: 3863489 (1975-02-01), Ayers et al.
Harris Joel M.
Knorr Fritz J.
Kreitman Stephen A.
University of Utah Research Foundation
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