Multichamber microdialysis device

Liquid purification or separation – Casing divided by membrane into sections having inlet – Dialyzer with dialysate proportioning means

Reexamination Certificate

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Details

C210S321750, C210S321720, C422S105000, C422S105000, C435S297100, C435S297200, C435S297500

Reexamination Certificate

active

10652938

ABSTRACT:
The invention is a multichamber microdialysis device with a multitude of sample chambers in close side by side arrangement (similar to a microtiter plate) for receiving liquid samples, and at least one dialysate chamber for receiving a dialysate liquid. The sample chambers are surrounded by circumferential sidewalls and are in liquid exchange contact to a neighboring dialysis chamber via an exchange opening covered by a semipermeable membrane. The semipermeable membrane is fixed liquid-tight to the walls of the sample chamber, so that a diffusion exchange between the sample chamber and the correspondingly neighboring dialysate chamber is only possible via the membrane. Consequently, only molecules with a molecular weight below the molecular cut-off of the semipermeable membrane can diffuse from the sample chamber to the dialysate chamber or from the dialysate chamber to the sample chamber.

REFERENCES:
patent: 5047215 (1991-09-01), Manns
patent: 5462874 (1995-10-01), Wolf et al.
patent: 5783075 (1998-07-01), Eddleman et al.
patent: 6039871 (2000-03-01), Sykaluk
patent: 6458275 (2002-10-01), Shukla et al.
patent: 6670173 (2003-12-01), Schels et al.
patent: G9105550.4 (1991-09-01), None
patent: 0596482 (1994-05-01), None
patent: WO 00/44877 (2000-08-01), None

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