Multicatalytic protease inhibitors

Details Multicatalytic protease inhibitors Multicatalytic protease inhibitors

1996-12-04

1998-11-03

Minnifield, Nita

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

564123, 554 36, 554 42, 554 51, 554 52, 554 54, 554 57, 558432, A61K 3800, C07C23100, C07C23500, C07C25500

Patent

active

058308709

ABSTRACT:
Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.

REFERENCES:
patent: 4499082 (1985-02-01), Shenvi et al.
patent: 4518528 (1985-05-01), Rasnick
patent: 4636492 (1987-01-01), Kettner et al.
patent: 4652552 (1987-03-01), Kettner et al.
patent: 5024994 (1991-06-01), Doherty et al.
patent: 5296468 (1994-03-01), Hoeger et al.
patent: 5340736 (1994-08-01), Goldberg
patent: 5550262 (1996-08-01), Iqbal et al.
patent: 5614649 (1997-03-01), Iqbal et al.
Stedman's Medical Dictionary, 24th Edition, Williams & Wilkins, Baltimore, 1982. see p. 206.
Allen et al., "Differential Requirements for Antigen Processing by Macrophages for Lysozyme-specific T Cell Hybridomas", J. Immunol. 1984, 132, 1077-1079.
Amsterdam, A. et al., "Changes in intracellular localization of proteasomes in immortalized ovarian granulosa cells during mitosis associated with a role in cell cycle control", PNAS USA, 90:99-103 (1993).
Armon, T. et al., "Assembly of the 26 S Complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity", J. of Biol. Chem., 265(34):20723-20726 (1990).
Arribas, J. et al., "Autoantibodies against the multicatalytic proteinase in patients with systemic lupus erthematosus", J. Exp. Med., 173:423-427 (1991).
Arrigo., A. -P., et al., "Identity of the 19S `prosome` particle with the large multifunctional protease complex of mammalian cells (the proteasome)", Nature 331:192-194 (1988).
Azaryan, A. et al., "The presence of ATp+ubiquitin-dependent proteinase and multicatalytic proteinase complex in bovine brain", Neurochemical Res., 14(10):995-1001 (1989).
Baldwin, J. et al., ".sup.11 B NMR studies of an aryl boronic acid bound to chymotrypsin and subtilisin", Bioorganic & Medicianl Chem. Letters, 1(1):9-12 (1991).
Bannister, J. et al., "Aspects of the structure, function, and applications of superoxide dismutase", CRC Critical Reviews in Biochemistry 22(2):111-179 (1987).
Bartel, B. et al., "The recognition component of the N-end rule pathway", The EMBO Journal 9(10):3179-3189 (1990).
Basak, A. et al., "Syntheses of argininal semicarbazone containing peptides and their applications in the affinity chromatography of serine proteinases", Int. J. Peptide Protein Res. 36:7-17 (1990).
Bewley, "cDNA and deduced amino acid sequence of murine Cu-Zn superoxide dismutase", Nucleic Acids Research 16(6):2728 (1988).
Borchelt, D. et al., "Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity", PNAS USA, 91:8292-8296 (1994).
Bowling, A. et al., "Superoxide dimutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis", J. of Neurochemistry 61:2322-2325 (1993).
Brown, M. et al., "Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes", Nature 353:355-357 (1991).
Brown, R.H. "Clinical Implications of Basic Research. A Transgenic-Mouse Model of Amyotrophic Lateral Sclerosis", NEJM 1994, 331(16), 1091-1092.
Cardozo, C. et al., "Evidence that the nature of amino acid residues in the P.sub.3 position directs substrates to distinct catalytic sites of the pituitary multicatalytic proteinase complex (proteasome)", Biochemistry 33:6483-6489 (1994).
Carrell and Boswell, Proteinase inhibitors, Barrett and Salvesen (eds.), Chap. 12, Elsevier Science Publishers BV (Biomedical Division) pp. 403-420 (1986).
Chau, V. et al., "A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein", Science, 243:1576-1583 (1989).
Chen and Okayama, "Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA", Biotechniques 1988, 6(7), 632-638.
Chu-Ping, M. et al., "Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain)", The J. of Biol. Chem. 267(15):1015-10523, (1992).
Chu-Ping, M. et al., "Purification and characterization of a protein inhibitor of the 20S proteasome (macropain)", Biochimica et Biophysica Acta, 1119:303-311 (1992).
Ciechanover, A. et al., "Degradation of nuclear oncoproteins by the ubiquitin system in vitro", PNAC USA 88:139-143 (1991).
Ciechanover and Schwartz, "The ubiquitin-mediasted proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins", The FASEB Journal 8:182-191 (1994).
Collins, D. et al., "Processing of exogenous liposome-encapsulated antigens in vivo generates class I MHC-restricted T cell responses", The J. of Immunol. 148(11):3336-3341 (1992).
DeMartino, G. et al., "The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous", Biochimica et Biophysica Acta 1079:29-38 (1991).
DeMartino, G. et al., "ATP-stimulated degradation of endogenous proteins in cell-free extracts of BHK 21/C13 fibroblasts A key role for the proteinase, macropain, in the ubiquitin-dependent degradation of short-lived proteins", Biochimica et Biophysica Acta 1073:299-308 (1991).
Deng, H.-H. et al., "Amyotrophic lateral sclerosis and structural defects in Cu, Zn Superoxide Dismutase", Science 261:1047-1051 (1993).
Dick, L. et al., "Degradation of Oxidized Insulin B Chain by the Multiproteinase Complex Macropain (Proteasome)", Biochemistry 1991, 30, 2725-2734.
Drechsel, D. et al., "Affinity chromatography of .alpha.-1-protease inhibitor using sepharose-4B-bound anhydrochymotrypsin", Anayltical Biochemistry 143:141-145 (1984).
Driscoll and Goldberg, "Skeletal muscle proteasome cna degrade proteins in an ATP-dependent process that does not require ubiquitin", PNAC USA 86:787-791 (1989).
Dubiel, W. et al., "Purification of an 11 S regulator of the multicatalytic protease", The J. of Biol. Chemistry, 267(31):22369-22377 (1992).
Driscoll, J. et al., "An ATP-stabilized inhibitor of the proteasome is a component of the 1500-kDa ubiquitin conjugate-degrading complex", PNAS USA 89:4986-4990 (1992).
Driscoll, J. et al., "MHC-linked IMP gene products specifically alter peptidase activities of the proteasome", Nature 365:262-264 (1993).
Dubiel, W. et al., "Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family", The J. of Biological Chemistry 267(32):22699-27702 (1992).
Eytan, E. et al., "ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin", PNAS USA 86:7751-7755 (1989).
Fagan and Waxman, "A novel ATP-requiring protease from skeletal muscle that hydrolyzes non-ubiquitinated proteins", The J. of Biological Chemistry 274(30) 17868-17872 (1989).
Fagan, J. et al., "Red blood cells contain a pathway for the degradation of oxidant-damaged hemoglobin that does not require ATP or ubiquitin", The J. of Biological Chemistry 261(13):5705-5713 (1986).
Falkenburg et al., "Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase", Nature 331:190-192 (1988).
Fruh, Klaus et al., "Alternative exon usage and processing of the major histocompatibility comoplex-encoded proteasome subunits", The J. Biiological Chem., 267(31):22131-22140 (1992).
Fujiwara, T. et al., "Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits", 265(27):16604-16613 (1990).
Fujiwara, T. et al., "Molecular cloning of cDNA for proteasomes multicatalytic proteinase complexes" from rat liver: primary structure of the largest component (C2), Biochemistry 28:7332-7340 (1988).
Furuno, K. et al., "Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy", The J. of Biological Chemistry 265(15):8550-8557 (1990).
Gaczynska, M. et al., ".gamma.-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasom

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