Multicapillary fluorescent detection system

Radiant energy – Luminophor irradiation

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2504591, 2504612, G01N 2164

Patent

active

056751559

ABSTRACT:
A detection system for sequentially and repetitively scanning a plurality of sample volumes and detecting electromagnetic radiation emitting from each of the sample volumes includes a plurality of coplanar side-by-side capillaries each containing a sample volume, an electromagnetic radiation source, a mirror aligned to receive and reflect electromagnetic radiation, a scanner for moving the mirror, and a detector aligned to receive electromagnetic radiation collected from the sample volumes. In operation, the scanner adjusts the mirror position so that the mirror is positioned to receive the electromagnetic radiation from the electromagnetic radiation source and reflect the electromagnetic radiation sequentially and repetitively to the sample volumes. Emitted electromagnetic radiation from the sample volume is collected and directed to a detector where a signal is generated in response to the interaction of the electromagnetic radiation with the sample.

REFERENCES:
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patent: 5371016 (1994-12-01), Berndt
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J. F. Black, C. J. Summers, and B. Sherman, "Scanned-Laser Microscope for Photoluminescence Studies." Applied Optics, vol. 11, No. 7 (Jul. 1972) pp. 1553-1562.
"Capillary Array Electrophoresis Using Laser-Excited Confocal Fluorescence Detection", X.C. Huang, M.A. Quesada, R.A. Mathies, Analytical Chemistry, vol. 64, No. 8, (Apr. 15, 1992) pp. 967-972.

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