Multiangle, multiwavelength particle characterization system and

Details Multiangle, multiwavelength particle characterization system and Multiangle, multiwavelength particle characterization system and

1997-01-10

1998-09-15

Font, Frank G.

Optics: measuring and testing

By dispersed light spectroscopy

With synchronized spectrum repetitive scanning

356311, 356300, 356301, 356303, G01J 306

Patent

active

058087389

ABSTRACT:
A system and method are provided for the characterization of a sample containing a macromolecule in solution. A light source illuminates the sample, generally in the ultraviolet-visible wavelength range, and a plurality of sensors that are radially disposed about the sample at a plurality of observation angles simultaneously sense the light energy emerging from the sample. An intensity spectrum is calculated as a function of wavelength for each observation angle, from which is calculated a particle characteristic such as shape, conformational change, composition, and particle size distribution. Both scattering and absorption data are utilized to provide complementary information.

REFERENCES:
patent: 2436104 (1948-02-01), Fisher
patent: 4900113 (1990-02-01), Hatori
patent: 5023804 (1991-06-01), Hoult

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