Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition
Reexamination Certificate
2000-10-02
2002-01-08
Beisner, William H. (Department: 1744)
Chemical apparatus and process disinfecting, deodorizing, preser
Control element responsive to a sensed operating condition
C422S065000, C435S288400, C435S305300
Reexamination Certificate
active
06337053
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a container which is suitable for an analysis inspection which requires a high quantitative accuracy. More particularly the present invention relates to the container by which all of the quantity of a specimen in the container can be substantially completely aspirated with being disposed a front end portion of a pipette tip in contact with a surface of the inside bottom of the container. Moreover, the present invention relates to the container which can largely enhance an efficiency of agitating by uniforming a diffusion of the specimen on the occasion of discharging it.
BACKGROUND OF THE INVENTION
In order to maintain a precision of an analysis in a high level, as is well-known, a quantitative precision by a pipette device must be exactly maintained. In case of a conventional container, an inside bottom part of the container is formed so as to have a plane surface or a vertical sectional shape being semicircle or substantially U-like. Therefore, aspirating or discharging a sample and/or a reagent can not be executed in a state that a front end part of a pipette tip remains to be disposed in contact with the inside bottom part of the container. As a result, aspirating or discharging a sample and a reagent can be executed in a situation that the front end part of the pipette tip is kept to be lifted from the inside bottom part of the container slightly. Consequently, a small amount of samples and reagents always remains behind the container. In order to compensate this remaining amount, more amount than the actually necessary amount of aspirating needs be aspirated and/or discharged by the pipette tip. Thus, it is inevitable that samples or reagents being not aspirated remain behind the container. As a result, it has a problem that a high quantitative analysis can not be executed.
A conventional means to solve such a problem is shown in
FIG. 16
for example. A front end part
2
of a pipette tip
1
is cut diagonally in order to be able to aspirate and discharge a sample S in a state that the front end part
2
of the pipette tip
1
is disposed in contact with an inside bottom part
4
of a container
3
. Also, as shown in
FIG. 18
, another conventional means in which has one or more caves
5
are mounted in the front end part of the pipette tip
1
, is proposed. It is designed so that an opening of the pipette tip
1
can not be blockaded by the contact with the inside bottom part
4
of the container
3
.
But, even if the front end part
2
of the pipette tip
1
is cut diagonally, the liquid below a level W in
FIG. 16
slightly lower than an upper rim of the opening of the front end part which is cut diagonally, can not be completely aspirated. As shown in
FIG. 17
, when the aspirated samples and/or reagents are discharged in the container
3
, those in the one side of the container
3
are agitated by the pressure of discharging. But, the other side of container
3
which does not face the above-mentioned opening cut diagonally, is not directly affected by the pressure of discharging. Therefore, the conventional means has a problem that the agitating efficiency on the opposite side of the opening is low and it is difficult to get a uniform agitating effect, i.e. a uniform state of reaction. Also, it has a problem that manufacture of the pipette tip is not easier and a cost of manufacture increases.
In the same way, the conventional means which is bored by caves
5
in the front end part of the pipette tip
1
, cannot aspirate a liquid S below the position where the caves
5
are bored, too. Also, when the aspirated liquid is discharged, the liquid is discharged only in the direction of the opening of the caves
5
. Therefore, the conventional means has the problem that it is difficult to get a uniform agitating effect. Moreover, as the manufacturing step to bore one or more caves
5
is necessary, the conventional means has a problem that the manufacture of pipette tip
1
is complicated and a manufacture cost increases.
When liquid is aspirated and discharged in a state that the front end part of the pipette tip is kept to be lifted from the surface of the bottom part of the container, samples or reagents are tend to stick to the outside surface of the pipette tip. Therefore, the conventional means has a problem that a concentration of a sample is changed by samples or reagents being stuck and has a problem that the conventional means is difficult to get high precision results.
The present invention has been accomplished under these circumstances and has the following objects.
It is a first object of the present invention to provide a container which can solve the above problems of the conventional arts by improvement.
It is a second object of the present invention to provide a container which enables the pipette means to execute a reliable step of dispensing and/or agitating by constituting so as to be able to aspirate and/or discharge in a predetermined quantity without blockading a front end part of a liquid sucking/discharging line, on the occasion of the aspirating and/or discharging samples and/or reagents in the container.
It is a third object of the present invention to provide a container which can realize a high precision inspection of all of the quantity by being able to aspirate all of the quantity in the container, and to treat all of the quantity as being fixed without necessity of the surplus of the samples and/or reagents.
It is a fourth object of the present invention to provide a container which can realize reducing a necessary space by accumulating vessels mounted in the container in a high density and moreover by providing the optimal containers for each process, and can realize the efficient process by reducing a transferring distance of the contents of the container, by a quick and prompt operation, and by saving energy.
It is a fifth object of the present invention to provide a container which has a simple structure, and is easy and inexpensive to manufacture by accumulating vessels in a high density.
It is a sixth object of the present invention to provide a container which can realize a prompt and efficient treatment by providing vessels having various capacity for treating, measuring and holding pipette tip, being necessary to the series of the process within a container.
It is a seventh object of the present invention to provide a container which can be so reliable as preventing from cross-contamination surely.
It is an eighth object of the present invention to provide a container which is suitable to attempt to automate a series of process and to exclude the participation of the operation of human being from beginning to end as much as possible.
It is a ninth object of the present invention to provide a container which can reduce a mechanical driving movement being necessary for the process from beginning to end and can realize such a container that the number of the moving parts for the process are reduced.
THE SUMMARY OF THE INVENTION
To achieve these objects, the container according to the first aspect of the present invention comprises a gap part formed near a center of an inside bottom part of the container to have a smaller width than a caliber of a front end portion of a liquid sucking/discharging line adapted to be inserted in the container and pulled out of the container, and a uniformly falling slope extending from an inside wall of the container toward a border of the gap part, wherein the gap part to have a shape being capable of aspirating and discharging all of the quantity of liquid through the front end portion even in a state that the front end portion is disposed in contact with the inside bottom part.
Thus, the reliable dispensing and/or agitating step by a pipette device can be realized by constituting so as to be able to aspirate and/or discharge a predetermined amount without blockading the front end portion of the liquid sucking/discharging line when the samples and/or reagents in container are aspirated and/or discharged. Moreover, as the present invention can
Beisner William H.
Precision System Science Co., Ltd.
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