Multi-substituted imidazolines and method of use thereof

Details Multi-substituted imidazolines and method of use thereof Multi-substituted imidazolines and method of use thereof

2010-01-26

2010-12-28

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07858808

ABSTRACT:
A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The combination of these two key characteristics provides an effective therapeutic drug in the treatment of septic shock as well as many other inflammatory (arthritis and asthma) and infectious disorders. The use of this novel class of non-steroidal agents as anti-inflammatory agents (for the treatment of asthma etc.), antibacterial agents and antiseptic agents is described. The compounds are also useful in the treatment of tumors (such as cancers). The imidazolines are potent inhibitors of the transcription factor NF-κB as well as potent activity against the Gram (+) bacteriumB. subtillusandB. cereuswith MIC values in the range of 50 μm/mL.

REFERENCES:
patent: 3354173 (1967-11-01), Godefroi et al.

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