Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-11-13
2000-12-19
Higel, Floyd D.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548460, 549416, 549432, 549439, 556482, 560 8, 560124, 568303, 568308, 568579, 568630, 568632, 568808, 558388, C07D40304, C07D40314, C07D40702
Patent
active
06162926&
ABSTRACT:
The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C.sub.n fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by .sup.3 He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.
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Lu Quing
Murphy Randall B.
Wilson Stephen R.
Evans, Esq. Barry
Higel Floyd D.
Sphere Biosystems, Inc.
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