Multi-stage cascade boosting vaccine

Details Multi-stage cascade boosting vaccine Multi-stage cascade boosting vaccine

1998-08-21

2000-10-17

Huff, Sheela

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Anti-idiotypic

4241301, 424 932, 424 937, 536 234, A61K 39395

Patent

active

061327182

ABSTRACT:
Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using a vaccine comprising antibodies and anti-idiotype antibodies that mimic an epitope of antigen that is associated with a tumor or infectious agent. Antibodies and cytokines also may be used to amplify the immune cascade. Moreover, antibodies and anti-idiotype antibodies can be used to produce T cells that are not MHC-restricted and that are targeted to tumor cells and infectious agents.

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