Fluid handling – Systems – With pump
Reexamination Certificate
2007-02-06
2007-02-06
Rivell, John (Department: 3753)
Fluid handling
Systems
With pump
C137S825000, C137S806000
Reexamination Certificate
active
10916270
ABSTRACT:
Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.
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Chien Ring-Ling
Chow Andrea W.
Kopf-Sill Anne
Parce J. Wallace
Caliper Life Sciences, Inc.
McKenna Donald R.
Petersen Ann C.
Rivell John
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