Compositions – Nonreactive analytical – testing – or indicating compositions
Patent
1978-08-22
1980-07-22
Gron, Teddy S.
Compositions
Nonreactive analytical, testing, or indicating compositions
23230B, 424 2, 424 3, 424101, 424164, 424258, 424310, G01N 3316, C09K 300
Patent
active
042138760
ABSTRACT:
A multi-purpose blood diluent especially suitable for use in electronic enumeration and sizing of blood cells, determination of hemoglobin concentration and their collective indices and platelet parameters in a single blood sample by means of suitable electronic instrumentation. The diluent is characterized as azide-free and capable of affording accurate, reproducible hematological test results from the said suitable electronic instrumentation. The diluent employs a chelating agent which functions as a bacteriostat and fungistat agent to prevent adverse growth of micro-organisms and a compatible stabilizing agent to maintain desired morphology of red blood cells and an inorganic metallic sulfate for suppressing turbidity caused by abnormal globulins and/or high leukocyte counts which are encountered in certain blood samples. Because of the capability for use of the diluent in platelet determinations by the instrumentation, the diluent further is free of detergent action which would cause bubbles capable of interfering with the enumeration of platelets by the instrumentation. A modified and adjusted embodiment of the diluent enables its use in veterinary laboratory testing applications.
REFERENCES:
patent: 3519572 (1970-07-01), Kita
patent: 3549994 (1970-12-01), Rothermel et al.
patent: 3873467 (1975-03-01), Hunt
patent: 3920400 (1975-11-01), Scheibe et al.
patent: 3920580 (1975-11-01), Mast
patent: 3962125 (1976-06-01), Armstrong
patent: 3977995 (1976-08-01), Louderdack et al.
patent: 4102810 (1978-07-01), Armstrong
Seeman, P., Biochemical Pharmacology, vol. 15, No. 11, pp. 1753-1766 (1966).
Fraser, R., et al., Biochem. J., vol. 147, pp. 401-410 (1975).
Baker, R. F., et al., Biochem. Biophys. Res. Communications, vol. 75, No. 2, pp. 381-388 (1977).
Palek, J., et al., Blood, vol. 50, No. 1, pp. 155-164 (1977).
Nachmias, V. T., et al., Blood, vol. 53, No. 1, pp. 63-72 (1969).
O'Brien, J. R., "The Adhesiveness of Native Platelets: SOM Anti-Adhesive Drugs and Their Modes of Action"; Proceedings of the Eight Congress of European Society of Hematology, 1961, Vienna, S. Karger, N. Y., 360 (1962).
Seeman, P., et al., Biochem, Pharmacology, vol. 15, pp. 1737-1752 (1966).
C. A., vol. 66, p. 922, 9673v (1967).
C. A., vol. 80, p. 52, 91564c (1974).
C. A., vol. 84, p. 103, 84739t (1976).
The Merck Index, Eighth Ed., Merck & Co., Inc., Rahway, N. J., p. 555, "8-Hydroxyquinoline" and Derivatives (1968).
Chastain, Jr. Dave
Crews Harold R.
Ledis Stephen L.
Coulter Electronics Inc.
Gron Teddy S.
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