Multi-plasmid method for preparing large libraries of...

Details Multi-plasmid method for preparing large libraries of... Multi-plasmid method for preparing large libraries of...

2006-05-23

2006-05-23

Nashed, Nashaat T. (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S183000, C536S023200, C536S023100, C536S023700

Reexamination Certificate

active

07049100

ABSTRACT:
A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS or NRPS products by tailoring enzymes.

REFERENCES:
patent: 5672491 (1997-09-01), Khosla et al.
patent: 5712146 (1998-01-01), Khosla et al.
patent: 5824513 (1998-10-01), Katz et al.
patent: 5830750 (1998-11-01), Khosla et al.
patent: 5843718 (1998-12-01), Khosla et al.
patent: 5958672 (1999-09-01), Short
patent: 5962290 (1999-10-01), Khosla et al.
patent: 5998194 (1999-12-01), Summers, Jr. et al.
patent: 6004787 (1999-12-01), Katz et al.
patent: 6022731 (2000-02-01), Khosla et al.
patent: 6033883 (2000-03-01), Barr et al.
patent: 6060234 (2000-05-01), Katz et al.
patent: 6063561 (2000-05-01), Katz et al.
patent: 6066721 (2000-05-01), Khosla et al.
patent: 6080555 (2000-06-01), Khosla et al.
patent: 6200813 (2001-03-01), Katz et al.
patent: 6271255 (2001-08-01), Leadlay et al.
patent: 6274560 (2001-08-01), Khosla et al.
patent: 6403775 (2002-06-01), McDaniel
patent: WO 96/40968 (1996-12-01), None
patent: WO 97/02358 (1997-01-01), None
patent: WO 98/01546 (1998-01-01), None
patent: WO 98/01571 (1998-01-01), None
patent: WO 98/49315 (1998-11-01), None
patent: WO 99/05283 (1999-02-01), None
patent: WO 00/24907 (2000-05-01), None
patent: WO 00/26349 (2000-05-01), None
patent: WO 00/31247 (2000-06-01), None
patent: WO 00/52152 (2000-09-01), None
August et al. (1998).Chem Biol5:69-79.
Betlach M.C. et al. (1998).Biochemistry37(42):14937-14942.
Cortes, et al. (1990).Nature348:176-178.
Donadio, et al. (1991).Science252:675-679.
Graziani E.I. et al. (1998).Bioorganic&Medicinal Chemistry Letters8(22):311703120.
Hutchinson C.R. (1999).Proc Natl Acad Sci USA96(7):3336-3338.
Jacobsen, et al. (1997).Science277:367-369.
Kao, et al. (1996).Biochemistry35:12363-12368.
Kao C.M. et al. (1994).Science265(5171):509-512.
Katz, et al. (1993).Annu Rev Microbiol47:875-912.
Khosla C. et al. (1996).Trends in Biotechnology14(9):335-341.
Liu, et al. (1997).J Am Chem Soc119:10553-10554.
Marahiel M.A. et al. (1997).Chem Reviews97(7):265102673.
Marsden, et al. (1998).Science279:199-202.
McDaniel, et al. (1997).J Am Soc119:4309-4310.
McDaniel, et al. (1999).Proc Natl Acad Sci USA96:1846-1851.
Olano C. et al. (1998).Mol and Gen Genetics259(3):299-308.
Patten, et al. (1997).Curr Op Biotechnol8:724-733.
Quiros et al. (1995).Chemistry270(31):18234-18239.
Ruan X. et al. (1997).J Bacteriol179(20):6416-6425.
Schneider A. et al. (1998).Mol and Gen Genetics257(3):308-318.
Schwecke, et al. (1995).Proc Natl Acad Sci USA92:7839-7843.
Tang L. et al. (2000).Science287(28):640-642.
Tang L. et al. (2000).Chem&Biol7(2):77-84.
Xue Y. et al. (1998).Proc Natl Acad Sci USA95(21):12111-12116.
Xue et al. (1999). 132:45550 Chemical Abstracts.
Xue Q. et al. (1999).Proc Natl Acad Sci USA96(21):11740-11745.

Affiliated with

Also associated with

Rating

Multi-plasmid method for preparing large libraries of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Multi-plasmid method for preparing large libraries of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multi-plasmid method for preparing large libraries of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3604519