Multi-organ technetium complexes production and use thereof

Details Multi-organ technetium complexes production and use thereof Multi-organ technetium complexes production and use thereof

1974-07-05

1976-08-24

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

2523011R, 25230115, 2605025, 424211, A61K 4300, G21H 502

Patent

active

039767620

ABSTRACT:
Chemical complexes, useful as radiopharmaceuticals, are formed by reacting technetium-99m with substituted or unsubstituted alkyl monophosphonic acids and certain ester derivatives thereof. The complexes are formed by reducing pertechnetate ion chemically or electrolytically in the presence of the phosphonic acid. By chemical modification of the phosphonic acid complexing agent, it is possible to "tailor" complexes for kidney, liver or bone imaging. The complexes are normally used in a physiologically acceptable aqueous medium.

REFERENCES:
patent: 3600470 (1971-08-01), Lewis
patent: 3725295 (1973-04-01), Eckelman et al.
patent: 3735001 (1973-05-01), McRae et al.
patent: 3851044 (1974-11-01), Adler et al.
patent: 3852414 (1974-12-01), Adler et al.
Subrumanian et al., Radiology, vol. 102, Mar., 1972, pp. 701-704.

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