Multi-media affinity column to prevent leaching of ligands

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification

Reexamination Certificate

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C436S161000, C210S198200

Reexamination Certificate

active

08053565

ABSTRACT:
In an affinity-type purification, ligands dissociated from a packed bed that would otherwise leach into the solution containing the species being purified are captured by a second ligand that resides in a porous barrier downstream from the packed bed, the second ligand exhibiting an affinity-type interaction with the dissociated first ligand with sufficient specificity to avoid the undesired retention by the second ligand of species from the liquid sample or source liquid other than the species sought to be purified in the affinity column.

REFERENCES:
patent: 5310688 (1994-05-01), Zale et al.
patent: 5683916 (1997-11-01), Goffe et al.
patent: 2008/0124812 (2008-05-01), Snyder et al.
Pikula et al. “Organic anion-transporting ATPase of rat liver. I. Purification, photoaffinity labeling, and regulation by phosphorylation,” J. Biol. Chem. 1994, vol. 269, No. 44, pp. 27566-27573.
A manual R-BIQPHARM AG, “RIDA Ochratoxin A column Immunoatflnity column for sample clean up prior to analysis of ochratoxin A,” Nov. 14, 2003, pp. 1-19.

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