Multi-layer wound dressing having oxygen permeable and oxygen im

Details Multi-layer wound dressing having oxygen permeable and oxygen im Multi-layer wound dressing having oxygen permeable and oxygen im

1986-04-03

1989-10-24

Apley, Richard J.

Surgery

Truss

Pad

128156, 604307, 4284246, A61F 1300, A61F 1500

Patent

active

048754730

ABSTRACT:
A multi-layer wound dressing is provided which facilitates wound healing by creating hypoxia followed, after 3 to 72 hours, by an aerobic environment. The dressing is made of (a) a low-oxygen permeability outer layer; (b) an oxygen permeable inner layer, affixed on one side to the outer layer; and (c) an adhesive applied to the other side of the inner layer. The adhesive may be applied in a continuous or discontinuous manner, and may be applied only around the perimeter of the dressing, leaving an adhesive-free window. The entire dressing is applied to the wound and creates a hypoxic environment until the outer low oxygen permeability layer is removed after 3 to 72 hours. The oxygen permeable layer is left on to provide protection during a subsequent aerobic healing phase.

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Oscar M. Alvarez, et al. Healing Wounds: Occlusion or Exposure, Infection in Surgery, pp. 173-181, Mar. 1984.
Oscar M. Alvarez, et al. The Effect of Occlusive Dressings on Collagen Synthesis and Re-epithelialization in Superficial Wounds, Journal of Surgical Research 35, 142-148 (1983).
David R. Knighton, et al. Regulation of Repair: Hypoxic Control of Macrophage Mediated Angiogenesis, pp. 41-49.

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