Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1994-10-04
1997-11-11
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514198, 514369, 514374, 514378, 514561, 514563, A61K 3156, A61K 3143, A61K 31425, A61K 31195
Patent
active
056864361
ABSTRACT:
Disclosed are methods for repressing reproduction of latent viruses, such as HIV, in animals by the generally concurrent administration of (1) antioxidants including a glutathione agent; and (2) an NFKB induction inhibitor. Also disclosed are pharmaceutical compositions and kits for use in repressing reproduction of latent viruses such as HIV.
REFERENCES:
Shreck, R. and Baeuerle, P.A., NF-Kappa-B as Inducible Transcriptional Activator of the Granulocyte-Macrophage Colony-Stimulating Factor Gene, Molecular and Cellular Biology, 10:(3)1281-1286, Mar. 1990.
Greenspan, D., Greenspan, J.S., Schiodt M., and Pindborg, J.J., AIDS and the Mouth, Munksgaard Publishing, Distributed by Mosby-Year Book, Inc., Chicago, IL, References to: Chapter 4--Human Immune Deficiency Viruses and Chapter 5--Animal Models for AIDS, 1990.
Schreck, R., Rieber, P., and Baeuerle, P.A., Reactive Oxygen Intermediates as Apparently Widely used Messengers in the Activation of the NF-Kappa-B Transcription Factor and HIV-1, EMBO J. 10(8): 2247-2258, 1991.
Lenardo, M.J., Baltimore, D., NF-Kappa-B: A Pleiotropic Mediator Inducible and Tissue-Specific Gene Control, Cell, vol. 58, pp. 227-229. Jul. 28, 1989.
Radi, R., Cosgrove, T.P., Beckman, J.S., and Freeman, B.A., Peroxynitrite-induced Luminol Chemiluminescence, J. Biochem, 290:51-57 1993.
Agostini, C., Trentin, L., Zambello, R., and Semenzato, G., HIV-1 and the Lung, Am. Review of Respirable Disease, 147:1038-1049, 1993.
Meltzer, M.S. and Gendelman, H.E., Mononuclear Phagocytes as Targets, Tissue Reservoirs, and ImmunoRegulatory Cells in Human Immunodeficiency Virus Disease, Current Topics in Microbiology and Immunology, 181:239-264, 1992.
Grimm, S. and Baeuerle, P.A., The Inducible Transcription Factor NF-Kappa-B Structure-Function Relationship of its Protein Subunits, Biochem. J. 290:297-308, 1993.
Segal, A.W. and Abo, A., The Biochemical Basis of the NADPH Oxidase of Phagocytes, Trends in Biol. Sci. 18:43-47, 1993.
Wang, J.F., Komarov, P., Sies, H., and Groot, H.D., Contribution of Nitric Oxide Synthase to Luminol-Dependent Chemiluminescence Generated by Phorbol-Ester-Activated Kupffer Cells, Biochem. J. 279:311-314, 1991.
Cathcart, R.F., III, Vitamin C in the Treatment of Acquired Immune Deficiency Syndrome (AIDS), Medical Hypothesis 14:423-433, 1984.
Mufson, R.A., Myers, C., Turpin, J.A., Meltzer, M., Phorbol Ester Reduces Constitutive Nuclear NF-Kappa-B and Inhibits HIV-1 Production in Mature Human Monocytic Cells, J. of Leukocyte Biology, 52:637-644, Dec. 1992.
Van Dyke, K., Drug Therapy in Acquired Immunodeficiency Syndrome (AIDS), Modern Pharmacology 4th Edition, Chapter 55:1-15.
Magnani, M., Rossi, L., Brandi, G., Schiavano, G., Montroni, M., and Piedimonte, G., Targeting Antiretroviral Nucleoside Analogues in Phosphorylated Form to Macrophages: In Vitro and in Vivo Studies, Proc. Natl. Acad. Sci. USA, 89:6477-6481, Jul. 1992.
Baeuerle, P.A., The Inducible Transcription Activator NF-Kappa-B; Regulation by Distinct Protein Subunits, Bochimica et Biophysica Acta, 1072:63-80, 1991.
Sherman, M.P., Aeberhard, E.E., Wong, V.Z., Griscavage, J.M., and Ignarro, L.J., Pyrrolidine Dithiocarbamate Inhibits Induction of Nitric Oxide Synthase Activity in Rat Alveolar Macrophages, Biochemical and Biophysical Research Communications, 191(3):1301-1308, Mar. 31, 1993.
Dorseuil, O., Vazquez, A., Lang P., Bertoglio, J., Gacon, G., Leca, G., Inhibition of Superoxide Production in B Lymphocytes by Rac Antisense Oligonucleotides, J. of Biol. Chem., 267(29):20540-20542, 1992.
Winkler, B.S., Orselli, S.M., Rex, T.S., The Redox Couple Between Glutathione And Ascorbic Acid: A Chemical And Physiological Perspective, Free Radical Biology & Medicine, vol. 17, No. 4, pp. 333-335, 1994.
Roederer, M., Ela, S.W., Staal, F.J.T., Herzenberg, L.A., Herzenberg, L.A., N-Acetylcysteine: A New Approach to Anti-HIV Therapy, Aids Research And Human Retroviruses, vol. 8, No. 2, 1992.
Dandekar, S., Beebe, A.M., Barlough, J., Phillips, T., Elder, J., Torten, M., Pedersen, N. Detection of Feline Immonodeficiency Virus (FIV) Nucleic Acids in FIV-Seronegative Cats, Journal of Virology, pp. 4040-4049, Jul., 1992.
White, A.C., Thannickal, V.J., Fanburg, B.L., Glutathione Deficiency in Human Disease, J. Nutr. Biochem., vol. 5, pp. 218-226, May, 1994.
Legrand-Poels, S., Vaira, D., Pincemail, J., De Vorst, A.V., Piette, J., Activation of Human Immunodeficiency Virus Type 1 by Oxidative Stress, AIDS Research And Human Retroviruses, vol. 6, No. 12, pp. 1389-1897, 1990.
Author Unknown, Questions & Answers about Sustained Release ONDROX.TM. Multi-Antioxidant Formulation, Unimed, Inc., 4 pages, 1992.
Halliwell, B. and Cross, C.E., Reactive Oxygen Species, Antioxidants and Acquired Immunodeficiency Syndrome, Arch Intern. Mod., vol. 151, pp. 29-31, Jan. 1991.
Bergamini, A., Capozzi, M., Ghlbeth, L., Olnl, L., Salanitro, A., Milanese, G., Wagner, T., Beninate, B., Peace, C.D., Amici, C., Rocchi, G., Cystamine Potently Suppresses In Vitro HIV Replication in Acutely and Chronically Infected Human Cells, J. Clin. Invest., vol. 93, pp. 2251-2257, May, 1994.
Barnes, P.J., Adcock, I., Anti-Inflammatory Actions of Steroids: Molecular Mechanisms, Tips Reviews, vol. 14, pp. 436-441, Dec., 1993.
Sodora, D.L., Shpaer, E.G., Kitchell, B.E., Dow, S.W., Hoover, E.A., Mullins, J.I., Identification of Three Feline Immunodeficiency Virus (FIV) env Gene Subtypes and Comparison of the FIV and Human Immunodeficiency Virus Type 1 Evolutionary Patterns, Journal of Virology, vol. 68, No. 4, pp. 2230-2238, Apr., 1994.
O'Neil, L. L., Burkhard, M. J., Diehl, L. J. and Hoover, E. A., "Vertical Transmission of Feline Immunodeficiency Virus", AIDS Research and Human Retroviruses, vol. 1, No. 1, pp. 171-182, 1995.
Zaccaro, L., Falcone, M. L., Silva, S., Bigalli, L., Cecchettini, A., Giorgi, F., Malvaldi, G. and Bendinelli, M., "Defective Natural Killer Cell Cytotoxic Activity in Feline Immunodeficiency Virus-Infected Cats", AIDS Research and Human Retroviruses, vol. 11, No. 6, pp. 747-752, 1995.
Witschi, A., Junker, E., Schranz, C., Speck, R. F. and Lauterburg, B. H., "Supplementation of N-Acetylcysteine Fails to Increase Glutathione in Lymphocytes and Plasma of Patients with AIDS", AIDS Research and Human Retroviruses, vol. 11, No. 1, pp. 141-143, 1995.
Essex, M., "The HIV-1 Vaccine Dilemma: Lessons From The Cat", The Journal of NIH Research, vol. 7, pp. 37-42, Mar., 1995.
Smyth, N.R., McCracken, C., Gaskell, R. M., Cameron, J.M., Coates, J.A.V., Gaskell, C.J., Hart, C.A. and Bennett, M., "Susceptibility in Cell Culture of Feline Immunodeficiency Virus To Eighteen Antiviral Agents", Journal of Antimicrobial Chemotherapy, vol. 34, pp. 589-594, 1994.
Vitkovic, L., Stover, E. and Koslow, S.H., "Animal Models Recapitulate Aspects of HIV/CNS Disease", AIDS Research and Human Retroviruses, vol. 11, No. 6, pp. 753-759, 1995.
Song, W., Collisson, E.W., Li, J., Wolf, A.M., Elder, J. H., Grant, C.K., and Brown, W.C., "Feline Immunodeficiency Virus (FIV)-Specific Cytotoxic T Lymphocytes from Chronically Infected Cats Are Induced in Vitro by Retroviral Vector-Transduced Feline T Cells Expressing the FIV Capsid Protein", Virology 209, pp. 309-399, 1995.
Johnson, C.M., Torres, B.A., Koyama, H. and Yamamoto, J.K., "FIV as a Model for AIDS Vaccination", AIDS Research and Human Retroviruses, vol. 10, No. 3, pp. 225-228, 1994.
Bennett, M. and Hart, C. A., "Feline Immunodeficiency Virus Infection--A Model For HIV and AIDS?", J. Med. Microbiol., vol. 42, pp. 223-236, 1995.
Andrieu, J., Lu, W. and Levy, R., "Sustained Increases in CD4 Cell Counts in Asymptomatic Human Immunodeficiency Virus Type 1--Seropositive Patients Treated with Predinisolone for 1 Year", The Journal of Infectious Diseases, 171, pp. 523-530, 1995.
Clerici, M., Bevilacqua, M., Vago, T., Villa, M.L., Shearer, G.M., Norbiato, G., "An Immunoendocrinological Hypothesis of HIV Infection", The Lancet, vol. 343, pp. 1552-1553, Jun. 18, 1994.
Sibille, P., Avrameas, A., Moraillon, A., Richardson, J., Sonigo, P., Pancino, G., Strosberg, A.D., "Comparison of Serological Tests for the Diagnosis of Feline
HIV Diagnostics, Inc.
Kishore Gollamudi S.
LandOfFree
Multi-faceted method to repress reproduction of latent viruses i does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Multi-faceted method to repress reproduction of latent viruses i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multi-faceted method to repress reproduction of latent viruses i will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1229268