Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2005-12-13
2005-12-13
Smih, Lynette R. F. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S184100, C424S193100, C424S203100, C424S234100, C435S069100, C435S069300
Reexamination Certificate
active
06974581
ABSTRACT:
A multi-component immunogenic composition confers protection on an immunized host against infection caused byHaemophilus influenzae. Such composition comprises at least two different antigens ofHaemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeableHaemophilus influenzaeenhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. TheHaemophilusvaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.
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Barenkamp et al. 1996. Identification of a second family of high-molecular-weight adhesion proteins expressed by non-typable Haemophilus influenzae. Molecular Microbiology. 19(6): 1215-1223.
Barenkamp . 1996. immunization with High-Molecular-Weight Adhesion Proteins of Nontypeable Haemophilus influenzae Modifies Experimental Otitis Media in Chinchillas. Inflection and Immunity. 64(4): 1246-1251, 1996.
Klein Michel H.
Loosmore Sheena M.
Yang Yan-Ping
Aventis Pasteur Limited
Hines Ja'Na
Smih Lynette R. F.
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