Multi-compartment separation in magnetic resonance using...

Electricity: measuring and testing – Particle precession resonance – Using a nuclear resonance spectrometer system

Reexamination Certificate

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C324S309000

Reexamination Certificate

active

07576535

ABSTRACT:
Disclosed is a method of quantitatively separating tissue signals based on relaxation time differences. The method uses the transient signal decay in steady-state free precession (balanced SSFP) imaging to provide an alternative to standard CPMG methods of T2-relaxometry. The balanced SSFP technique allows 3-4 times the temporal resolution of CPMG, and also slows the short T2decay so that it can be more accurately measured.

REFERENCES:
patent: 6339332 (2002-01-01), Deimling
patent: 6452387 (2002-09-01), Hargreaves et al.
patent: 2005/0085713 (2005-04-01), Reeder et al.
Hargreaves et al. Characterization and Reduction of the Transient Response in Steady-State MR Imaging, Magn Reson Med. Jul. 2001; 46(1):149-158.
Hargreaves, Brian A. and Nishimura, Dwight G., “Relaxometry using Transient Steady-Sate Free Precession Imaging”, International Society for Magnetic Resonance in Medicine, 11thAnnual Meeting, Poster #1100, Jul. 10, 2003, 1 page.
Harrison et al., “Magnetization Transfer and T2Relaxation Components in Tissue”, MRM, Dec. 24, 1994, vol. 33, pp. 490-496.
Whithall, Kenneth P. and MacKay, Alexander L., “Quantitative Interpretation of NMR Relaxation Data”, Journal of Magnetic Resonance, Nov. 22, 1988, vol. 84, pp. 134-152.

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