Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus
Reexamination Certificate
2007-12-18
2007-12-18
Nguyen, Nam (Department: 1753)
Chemistry: electrical and wave energy
Apparatus
Electrophoretic or electro-osmotic apparatus
C204S605000, C204S616000, C204S612000
Reexamination Certificate
active
10059993
ABSTRACT:
A bio-separation system using an efficient, compact, portable, interchangeable, reusable, recyclable, multi-channel cartridge, has integrated pre-aligned optics and an integrated reagent reservoir. The cartridge supports, for example, multiple capillaries for CE separation. An integrated reservoir containing a separation support medium (e.g., a gel buffer) is common to all capillaries. The chemistry of the medium and the characteristics of the capillaries (e.g., capillary size, coating and length) are defined for each cartridge. Different cartridges can be easily interchanged in the bio-separation system to suit the particular sample based separation. The reservoir is coupled to an air pressure pump that pressurizes the gel reservoir to purge and fill the capillaries with buffer as the separation support medium. In another aspect of the present invention, optics requiring fine alignment with respect to the detection zones (such as fiber optics for directing incident radiation and/or radiation emissions) are integrated into the cartridge.
REFERENCES:
patent: 4417967 (1983-11-01), Ledley
patent: 4827780 (1989-05-01), Sarrine et al.
patent: 5062942 (1991-11-01), Kambara et al.
patent: 5066382 (1991-11-01), Weinberger et al.
patent: 5192412 (1993-03-01), Kambara et al.
patent: 5198091 (1993-03-01), Burolla et al.
patent: 5324401 (1994-06-01), Yeung et al.
patent: 5338427 (1994-08-01), Shartle et al.
patent: 5366608 (1994-11-01), Kambara
patent: 5413686 (1995-05-01), Klein et al.
patent: 5416879 (1995-05-01), Liu et al.
patent: 5439578 (1995-08-01), Dovichi et al.
patent: 5498324 (1996-03-01), Yeung et al.
patent: 5529679 (1996-06-01), Takahashi et al.
patent: 5543018 (1996-08-01), Stevens et al.
patent: 5560811 (1996-10-01), Briggs et al.
patent: 5584982 (1996-12-01), Dovichi et al.
patent: 5625403 (1997-04-01), Hazman et al.
patent: 5635050 (1997-06-01), Pentoney et al.
patent: 5650846 (1997-07-01), Yin et al.
patent: 5675155 (1997-10-01), Pentoney, Jr. et al.
patent: 5741411 (1998-04-01), Yeung et al.
patent: 5741412 (1998-04-01), Dovichi et al.
patent: 5763277 (1998-06-01), Zhu et al.
patent: 5790727 (1998-08-01), Dhadwal et al.
patent: 5846727 (1998-12-01), Soper et al.
patent: 5865974 (1999-02-01), Cabilly et al.
patent: 5916428 (1999-06-01), Kane et al.
patent: 5968331 (1999-10-01), Kambara et al.
patent: 6001230 (1999-12-01), Burolla
patent: 6013165 (2000-01-01), Wiktorowicz et al.
patent: 6017765 (2000-01-01), Yamada et al.
patent: 6027627 (2000-02-01), Li et al.
patent: 6043880 (2000-03-01), Andrews et al.
patent: 6054032 (2000-04-01), Haddad et al.
patent: 6063251 (2000-05-01), Kane et al.
patent: 6074827 (2000-06-01), Nelson et al.
patent: 6084667 (2000-07-01), Melman et al.
patent: 6103083 (2000-08-01), Merenkova et al.
patent: 6104485 (2000-08-01), Wang et al.
patent: 6132578 (2000-10-01), Kambara et al.
patent: 6153437 (2000-11-01), Horn
patent: 6184990 (2001-02-01), Amirkhanian et al.
patent: 6326213 (2001-12-01), Letcher et al.
patent: RE37606 (2002-03-01), Guttman
patent: 6369893 (2002-04-01), Christel et al.
patent: 6375819 (2002-04-01), Li et al.
patent: 6445448 (2002-09-01), Melman et al.
patent: RE37941 (2002-12-01), Guttman
patent: 6752914 (2004-06-01), Hassard
patent: 6828567 (2004-12-01), Amirkhanian et al.
patent: 6870165 (2005-03-01), Amirkhanian et al.
patent: 2002/0092770 (2002-07-01), Hedberg et al.
patent: 2002/0113213 (2002-08-01), Amirkhanian et al.
patent: 2003/0052008 (2003-03-01), Liu et al.
patent: 2003/0116436 (2003-06-01), Amirkhanian et al.
patent: 2003/0178312 (2003-09-01), Amirkhanian et al.
patent: 0021499 (1981-01-01), None
patent: 0631134 (1994-12-01), None
patent: 0723149 (1996-07-01), None
patent: 7174701 (1995-07-01), None
patent: 8136502 (1996-05-01), None
patent: 10-206384 (1998-08-01), None
patent: 11023533 (1999-01-01), None
patent: 11230938 (1999-08-01), None
patent: 2001-124736 (2001-05-01), None
patent: WO98/10122 (1998-03-01), None
patent: 9813667 (1998-04-01), None
patent: WO00/06996 (2000-02-01), None
patent: WO01/02846 (2001-01-01), None
patent: WO 02/28509 (2002-04-01), None
patent: WO 02/059589 (2002-08-01), None
Taylor et al, “Axial-Beam Laser-Excited Fluorescence Detection in Capillary Electrophoresis,” Anal. Chem., (1992), vol. 64, pp. 1741-1744.
Taylor et al, “Multiplexed Fluorescence Detector for Capillary Electrophoresis Using Axial Optical Fiber Illumination,” Anal. Chem., (1993), vol. 65, pp. 956-960.
Ueno et al, “Simultaneous Monitoring of DNA Fragments Separated by Electrophoresis in a Multiplexed Array of 100 Capillaries,” Anal. Chem., vol. 66, No. 9, pp. 1424-1431, May 1, 1994.
The New Encyclopaedia Britannica, 15th Edition, vol. 25, (1994), p. 202.
Quesada, M.A., Zhang, S., Multiple capillary DNA sequencer that uses fiber-optic illumination and detection, Electrophoresis, 17, 1996, pp. 1841-1851.
International Search Report of Counterpart PCT Application No. PCT/US02/02514, Oct. 18, 2002.
International Search Report of Counterpart PCT Application No. PCT/US03/01841, Jul. 7, 2003.
“Low-Cost, High-Sensitivity Laser-Induced Fluorescence Detection for DNA Sequencing by Capillary Gel Electrophoresis”, Chen, et al., Journal of Chromatography, vol. 559, 1991, pp. 237-246.
“Multiple Capillary DNA Sequencer that Uses Fiber-Optic Illumination and Detection”, by Quesada, et al., Electrophoresis, vol. 17, 1996, pp. 1841-1851.
International Search Report of Counterpart PCT Application No. PCT/US02/02515, Feb. 11, 2003.
Partial International Search Report of Counterpart PCT Application No. PCT/US2004/043424.
Simultaneous Monitoring of DNA Fragments Separated by Electrophoresis in a Multiplexed Array of 100 Capillaries, year not available.
DNA Analysis Tools Shrink, year not available.
An Integrated Nanoliter DNA Analysis Device, year not available.
DNA Sequencing Using Capillary Array Electrophoresis, year not available.
Three DNA Sequencing Methods Using Capillary Gel Electrophoresis and Laser-Induced Fluorescence, year not available.
DNA Sequencing by Multiple Capillaries that Form a Waveguide, year not available.
A Capillary Array Gel Electrophoresis System Using Multiple Laser Focusing for DNA Sequencing, year not available.
Researchers Design DNA Lab on a Chip, year not available.
Laser-Induced Fluorescence Detection of a Single Molecule in a Capillary, year not available.
Up to Speed on PCR, year not available.
Low-Cost, High-Sensitivity Laser-Induced Fluorescence Detection for DNA Sequencing by Capillary Gel Electrophoresis, year not available.
Electrophoresis, 1996, 17, 1845-1851.
Taylor et al, Axial-Beam Laser-Excited Fluorescence Detection in Capillary Electrophoresis, Anal. Chem. 1992, vol. 64, 1741-1744.
Taylor et al, Multiplexed Fluorescence Detector for Capillary Electrophoresis Using Axial Optical Fiber Illumination, Anal. Chem. 1993, vol. 65, 956-960.
“Simultaneous Monitoring of DNA Fragments Separated by Electrophoresis in a Multiplexed Array of 100 Capillaries”, by Ueno, et al., Analytical Chemistry, vol. 66, No. 9, May 1, 1994, pp. 1424-1431.
“DNA Analysis Tools Shrink”, by Richard Gaughan, Biophotonics International, Jul./Aug. 2000, pp. 18-19.
“An Integrated Nanoliter DNA Analysis Device”, by Burns, et al., Science, vol. 282, Oct. 16, 1998, pp. 484-487.
“DNA Sequencing Using Capillary Array Electrophoresis”, by Huang, et al., Analytical Chemistry, vol. 64, No. 18, Sep. 15, 1992, pp. 2149-2154.
“Three DNA Sequencing Methods Using Capillary Gel Electrophoresis and Laser-Induced Fluorescence”, by Swerdlow, et al., Analytical Chemistry, vol. 63, No. 24, Dec. 15, 1991, pp. 2835-2841.
“DNA Sequencing by Multiple Capillaries that Form a Waveguide”, by Dhadwal, et al., pp. 1-14, year not available.
“A Capillary Array Gel Electrophoresis System Using Multiple Laser Focusing for DNA Sequencing”, by Anazawa, et al., Analytical Chemistry, vol. 68, No. 15, Aug. 1, 1996, pp. 2699-2704.
“Researchers Design DNA Lab on a Chip”, by Kate Legg
Amirkhanian Varouj
Liu Ming-Sun
Mooney Paul
Biocal Technology, Inc.
Fick Anthony
Liu & Liu
Nguyen Nam
LandOfFree
Multi-channel bio-separation cartridge does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Multi-channel bio-separation cartridge, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multi-channel bio-separation cartridge will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3869132