Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer
Reexamination Certificate
2011-07-12
2011-07-12
Hartley, Michael G (Department: 1618)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Aftertreated polymer
C424S078080, C424S078180, C424S078370
Reexamination Certificate
active
07976834
ABSTRACT:
The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.
REFERENCES:
patent: 5395885 (1995-03-01), Kennedy et al.
patent: 5594072 (1997-01-01), Handlin et al.
patent: 5618528 (1997-04-01), Jones et al.
patent: 6150468 (2000-11-01), Schoenberg et al.
patent: 6228945 (2001-05-01), Kennedy et al.
patent: 6328988 (2001-12-01), Uhrich
patent: 6469132 (2002-10-01), Eisenberg et al.
patent: 7316811 (2008-01-01), Zhao et al.
patent: 2002/0032309 (2002-03-01), Deming et al.
patent: 2002/0041898 (2002-04-01), Unger et al.
patent: 2004/0161403 (2004-08-01), Zhao et al.
patent: 00/65024 (2000-11-01), None
patent: 03/055935 (2003-07-01), None
European Examination Report in European Application No. 03814969.6 dated Oct. 13, 2005.
European Examination Report in European Application No. 03814969.6 dated May 15, 2006.
European Examination Report in European Application No. 038124969.6 dated Apr. 17, 2008.
PCT International Search Report in PCT Application No. PCT/US2003/41332 mail date May 11, 2004.
Adams, et al., “Amphiphilic Block Copolymers for Drug Delivery”, J. of Pharm Sci., Jul. 2003; pp. 1343-1355, vol. 92, No. 7.
Anderson, et al., “Folic acid-PEO-labeled liposomes to improve gastrointestinal absorption of encapsulated agents”, J. of Controlled Release, 1999; pp. 189-198, vol. 60.
Breitenbach, et al., “Branched biodegradable polyesters for parenteral drug delivery systems”, J. of Controlled Release, 2000; pp. 167-178, vol. 64.
Caponetti, et al., “Microparticles of Novel Branched Copolymers of Lactic Acid and Amino Acids: Preparation and Characterization”, J. of Pharm Sci., Jan. 1999; pp. 136-141, vol. 88, No. 1.
Dagani, “Chemists Explore Potential Of Dendritic Macromolecules As Functional Materials Hyperbranched polymers and dendrimers are being eyed as drug-delivery agents, micelle mimics, and nanoscale building blocks”, Chemical & Engineering News, Jun. 3, 1996.
Henry, “Block Polypeptide Hydrogels: Material formed at low concentration could find use in tissue engineering”, Chemical & Engineering News, May 27, 2002; p. 14.
Jeong, et al., “New biodegradable polymers for Injectable drug delivery systems”, J. of Controlled Release, 1999; pp. 109-114, vol. 62.
La, et al., “Preparation and Characterization of the Micelle-Forming Polymeric Drug Indomethacin-Incorporated Poly(ethylene oxide)-Poly(B-benzyl L-aspartate) Block Copolymer Micelles”, J. of Pharm. Sci., Jan. 1996; pp. 85-90, vol. 85, No. 1.
Lavasanifar, et al., “Block Copolymer Micelles for the Encapsulation and Delivery of Amphotericin B”, Pharmaceutical Research, Apr. 2002; pp. 418-422, vol. 19, No. 4.
Lavasanifar, et al., “The effect of fatty acid substitution on the in vitro release of amphotericin B from micelles composed of poly(ethylene oxide)-block-poly(N-hexyl stearate-L-aspartamide)”, J. of Controlled Release, 2002; pp. 165-172, vol. 79.
Lavasanifar, et al., “Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery”, Advanced Drug Delivery Reviews, 2002; pp. 169-190, vol. 54.
Liu, et al., “Water-soluble dendritic unimolecular micelles: Their potential drug delivery agents”, J. of Controlled Release, 2000; pp. 121-131, vol. 65.
Petersen, et al., “The macrostopper-Route: A New Synthesis Concept Leading Exclusively to Diblock Copolymers with Enhanced DNA Condensation Potential”, Macromolecules, 2002; pp. 9854-9856. vol. 35.
Veronese, “Peptide and protein PEGylation: a review of problems and solutions”, Biomaterials, 2001; pp. 405-417, vol. 22.
Yarnell, “22ndAmino Acid Identified: Methanogen uses stop codon to genetically encode L-pyrrolysine”, Chemical & Engineering News, May 27, 2002; p. 13.
Shearwater Polymers, Inc., p. 2-49, (Catalog—Mar. 1995).
Shearwater Polymers, Inc., Polyethylene Glycol and Derivatives, pp. 1-53, (Catalog—Jul. 1997).
Shearwater Polymers, Inc., Polyethylene Glycol and Derivatives: Functionalized Biocompatible Polymers for Research and Pharmaceuticals, pp. 1-50, (Catalog—2000).
Shearwater Corporation, Polyethylene Glycol and Derivatives for Biomedical Applications, pp. 1-17, (Catalog—2001).
Emoto Kazunori
Ren Zhongxu
Zhao Xuan S.
Hartley Michael G
Nektar Therapeutics
Rogers James W
Wilson Mark A.
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