Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer
Reexamination Certificate
2004-09-17
2010-06-29
Silverman, Eric E (Department: 1618)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Aftertreated polymer
C424S426000
Reexamination Certificate
active
07744861
ABSTRACT:
Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
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Bentley Michael D.
Ren Zhongxu
Viegas Tacey X.
Zhao Xuan
Dickinson Paul
Evans Susan T.
Nektar Therapeutics
Silverman Eric E
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