Multi-arm cyclic or cubic siloxane-based formulations for...

Details Multi-arm cyclic or cubic siloxane-based formulations for... Multi-arm cyclic or cubic siloxane-based formulations for...

2006-08-07

2010-06-29

Gulakowski, Randy (Department: 1796)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

C524S588000, C528S010000

Reexamination Certificate

active

07745547

ABSTRACT:
The present invention provides multi-arm siloxane-based molecules suitable for use as a drug delivery vehicle comprising a central core molecule that comprises a cyclic or cubic siloxane, and a plurality of arms attached to the central core molecule, wherein each arm comprises an organic moiety. The multi-arm siloxane-based molecules described herein are suitable for encapsulation of a therapeutic agent. The invention further includes pharmaceutical compositions comprising the claimed multi-arm siloxane-based molecules and an encapsulated therapeutic agent in combination with a pharmaceutically acceptable carrier. Methods of making and using the multi-arm siloxane-based molecules are also provided.

REFERENCES:
patent: 5443747 (1995-08-01), Inada et al.
patent: 6528584 (2003-03-01), Kennedy et al.
patent: 6660822 (2003-12-01), Lyu et al.
patent: 2003/0232944 (2003-12-01), Molenberg et al.
patent: 2005/0090607 (2005-04-01), Tapsak et al.
patent: 1074244 (2001-07-01), None

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