Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Reexamination Certificate
2005-01-04
2005-01-04
Truong, Duc (Department: 1711)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
C525S231000, C525S326900, C525S328800, C528S354000, C528S425000, C424S780000, C424S422000, C424S078080
Reexamination Certificate
active
06838528
ABSTRACT:
The invention provides multi-arm block copolymers useful as drug delivery vehicles comprising a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, methods of making such copolymers and pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.
REFERENCES:
patent: 3101374 (1963-08-01), Patton, Jr.
patent: 4278555 (1981-07-01), Zaweski et al.
patent: 4894238 (1990-01-01), Embry et al.
patent: 5135751 (1992-08-01), Henry et al.
patent: 5306501 (1994-04-01), Viegas et al.
patent: 5429826 (1995-07-01), Nair et al.
patent: 5543158 (1996-08-01), Gref et al.
patent: 5610241 (1997-03-01), Lee et al.
patent: 5618528 (1997-04-01), Cooper et al.
patent: 5672662 (1997-09-01), Harris et al.
patent: 5681576 (1997-10-01), Henry
patent: 5874500 (1999-02-01), Rhee et al.
patent: 5932462 (1999-08-01), Harris et al.
patent: 5965566 (1999-10-01), Greenwald et al.
patent: 6011042 (2000-01-01), Greenwald et al.
patent: 6051648 (2000-04-01), Rhee et al.
patent: 6096331 (2000-08-01), Desai et al.
patent: 6166130 (2000-12-01), Rhee et al.
patent: 6210717 (2001-04-01), Choi et al.
patent: 6258351 (2001-07-01), Harris
patent: 6323278 (2001-11-01), Rhee et al.
patent: 6328988 (2001-12-01), Uhrich
patent: 6348558 (2002-02-01), Harris et al.
patent: 6362276 (2002-03-01), Harris et al.
patent: 6436425 (2002-08-01), Henry et al.
patent: 6497895 (2002-12-01), Uhrich
patent: 6515100 (2003-02-01), Harris
patent: 20020013408 (2002-01-01), Rhee et al.
patent: 20020041898 (2002-04-01), Unger et al.
patent: 20030059465 (2003-03-01), Unger et al.
patent: 20040009229 (2004-01-01), Unger et al.
patent: 0 462 408 (1991-12-01), None
patent: 0 473 268 (1992-03-01), None
patent: WO 9200748 (1992-01-01), None
patent: WO 9603984 (1996-02-01), None
patent: WO 9929303 (1999-06-01), None
patent: WO 9945964 (1999-09-01), None
patent: WO 0065024 (2000-11-01), None
patent: WO 0149268 (2001-07-01), None
Choi et al., “Star-Shaped Poly(ether-ester) Block Copolymers: Synthesis, Characterization, and Their Physical Properties”,Macromolecules, 1998, pp. 8766-8774, vol. 31, No. 25.
Choi, Young Kweon, “Biodegradable Star-Shaped Block Copolymer Hydrogels for Drug Delivery”, Dissertation, The University of Utah, Department of Pharmaceutics and Pharmaceutical Chemistry, Jun. 1996, pp. 1-229.
Gayet, J.-C., and G. Fortier, “High Water Content BSA-PEG Hydrogel for Controlled Release Device: Evaluation of the Drug Release Properties,”Journal of Controlled Release, 1996, pp. 177-184, vol. 38.
Harris, J. Milton, “Introduction to Biotechnical and Biomedical Applications of Poly(Ethylene Glycol)”,Poly(Ethylene Glycol)Chemistry: Biotechnical and Biomedical Applications, 1992, pp. 1-14.
Jain et al., “Controlled release of drugs from injectable in situ formed biodegradable PLGA microspheres: effect of various formulation variables”,European Journal of Pharmaceutics and Biopharmaceutics, 2000, pp. 257-262, vol. 50, No. 2.
Jeong et al., “Adriamycin release from flower-type polymeric micelle based on star-block copolymer composed of poly(γ-benzyl L-glutamate) as the hydrophobic part and poly(ethylene oxide) as the hydrophilic part”,International Journal of Pharmaceutics, 1999, pp. 49-58, vol. 188.
Jeong et al., “New biodegradable polymers for injectable drug delivery systems”,Journal of Controlled Release, 1999, pp. 109-114, vol. 62.
Jeong, B., et al., “Biodegradable Block Copolymers as Injectable Drug-Delivery Systems,”Nature, 1997, pp. 860-862, vol. 388.
Lewis, Richard J., Sr.,Hawley's Condensed Chemical Dictionary, 1997, pp. 891-892 and 1092-1093, Thirteenth Edition, John Wiley & Sons, Inc.
Liu et al., “Water-soluble dendritic unimolecular micelles: Their potential as drug delivery agents”,Journal of Controlled Release, 2000, pp. 121-131, vol. 65.
Piskin et al., “Novel PDLLA/PEG copolymer micelles as drug carriers”,J. Biomater. Sci. Polymer Edn, 1995, pp. 359-373, vol. 7, No. 4.
Pistel et al., “Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and star-branched block copolymers: Influence of encapsulation technique and polymer composition on particle characteristics”,Journal of Controlled Release, 1999, pp. 309-325, vol. 59.
Roubi, Maureen, “Hyperbranched polymers deliver drugs steadily”,Chemical&Engineering News, 1999, p. 63, vol. 77, No. 03.
Sawhney, A., et al., “Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly(α-hydroxy acid) Diacrylate Macromers,”Macromolecules, 1993, pp. 581-587, vol. 26.
Schmalenberg et al., “Cytotoxicity of a Unimolecular Polymeric Micelle and Its Degradation Products”,Biomacromolecules, 2001, pp. A-E.
Yasugi et al., “Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block copolymers as potential drug carrier”,Journal of Controlled Release, 1999, pp. 89-100, vol. 62.
Yu et al., “Polymeric micelles for drug delivery: solubilization and haemolytic activity of amphotericin B”,Journal of Controlled Release, 1998, pp. 131-136, vol. 53.
Zalipsky et al., “Attachment of Drugs to Polyethylene Glycols”,Eur. Polym. J., 1983, pp. 1177-1183, vol. 19, No. 12.
Zalipsky, Samuel, “Chemistry of polyethylene glycol conjugates with biologically active molecules”,Advanced Drug Reviews, 1995, pp. 157-182, vol. 16.
Alston & Bird LLP
Nektar Therapeutics AL, Corporation
Truong Duc
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