Multi-anode detector with increased dynamic range for...

Radiant energy – Ionic separation or analysis – Methods

Reexamination Certificate

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C250S287000

Reexamination Certificate

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06909090

ABSTRACT:
A detection scheme for time-of-flight mass spectrometers is described that extends the dynamic range of spectrometers that use counting techniques while avoiding the problems of crosstalk. It is well known that a multiple anode detector capable of detecting different fractions of the incoming particles may be used to increase the dynamic range of a TOFMS system. However, crosstalk between the anodes limits the amount by which the dynamic range may be increased. The present invention overcomes limitations imposed by crosstalk by using either a secondary amplification stage or by using different primary amplification stages.

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Barbacci, D. C., et al.—Multi-node Detection in Eloctrospray Ionization Time-of-Flight Mass Spectrometry; J Am Soc Mass Spectrom 1998, 9, 1328-1333; Elsevier Science, Inc., College Station, TX 77843, Brazos County, Texas.
Kristo, et al.—System for simultaneous count/current measurement with a dual-mode photon/particle detector; 1988 American Institute of Physics, Rev. Sci. Instrum. .59(3), Mar. 1988, pp. 438-442; Michigan State University, East Lansing, Michigan

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