Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-12-04
2007-12-04
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
11132977
ABSTRACT:
A HECT-domain containing E3 ubiquitin ligase that mediates the polyubiquitination of Mcl-1, named Mule for Mcl-1 ubiquitin ligase E3, is described. Methods and compositions for modulating functional interaction between Mcl-1 and Mule protein and Mcl-1 mediated apoptosis are described. Diagnostic and prognostic methods based on Mule expression in patient cells are also described.
REFERENCES:
Nandi et al J Biosci, 2006, 31:137-155.
World wide web.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=protein (Mule E3 ubiquitin ligase).
Du Fenghe
Gao Wenhua
Wang Xiaodong
Zhong Qing
Board of Regents , The University of Texas System
Halvorson Mark
Osman Richard Aron
Yu Misook
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