Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1997-08-15
2000-02-29
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424 932, 4242441, 4352523, 4352528, A61K 3902, A61K 3909, C12N 121
Patent
active
060306246
ABSTRACT:
The present invention provides chimeric proteins such as Salivary Binding Protein (SBR) coupled to the B subunit of cholera toxin. Such a chimeric protein, when expressed in attenuated Salmonella typhymurium produces significant increases in serum IgG and salivary IgA antibody levels after oral immunization. In another embodiment of the present invention, the recombinant plasmid contains a salivary binding protein-cholera toxin A2/B chimeric protein expressed in E. coli. Intragastric immunization of SBR coupled to CTB in this chimeric protein form leads to increased antigen responsive T cells. In another embodiment of the present invention, the recombinant plasmid contains a salivary binding protein-cholera toxin.sup..DELTA.A1 chimeric protein expressed in Salmonella typhimurium. Oral immunization using this recombinant plasmid results in increased serum IgG responses to antigen. Oral immunization using this recombinant plasmid also resulted in increased salivary IgA antibody responses to antigen.
REFERENCES:
Hajishengallis et al. Journal of Immunology 154 (9): 4322-32, May 1, 1995.
Redman et al . Infection and Immunity 63 (5): 2004-2011, May 1995.
Hajishengallis Georgios
Hollingshead Susan K.
Michalek Suzanne Mary
Russell Michael William
Wu Hong-Yin
Adler Benjamin Aaron
Mosher Mary E.
UAB Research Foundation
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