Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2011-02-15
2011-02-15
Azpuru, Carlos A (Department: 1617)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
Reexamination Certificate
active
07887829
ABSTRACT:
The present invention discloses a composite made of a layer of epithelial cells cultured together with a dermal matrix in a culture medium, which is free of BPE. The dermal matrix is a substantially non-immunogenic human dermis. Also disclosed is an enhanced composite where a biological agent has been introduced into the epithelial cells. The invention also comprises methods of making and implanting both the composite and the enhanced composite in an animal. A method of treating disease or injury through the use of the disclosed composites is also part of the present invention.
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AAOMS, 1999; Poster 46, Development of an Ex Vivo Produced Full Thickness Conjunctival Graft, Yoshizawa, p. 127.
J Oral Maxillofac Surg; 57:571-577, 1999; Ex-Vivo Development of a Composite Human Oral Mucosal Equivalent, Izumi, et al.
J. Dent Res 79(3): 798-805, 2000; Development and Characterization of a Tissue-engineered Human Oral Mucosa Equivalent Produced in a Serum-free Culture System, Izumi, et al.
AAOMS, 2001; Clinical Application of a Tissue-Engineered Ex Vivo-Produced Oral Mucosa Equivalent: A Preliminary Report; Izumi, et al., pp. 23-24.
AAOMS, 2001; A Tissue-Engineered Human Oral Mucosa: A New Approach Toward Clinical Application Xue, et al. p. 25.
Feinberg Stephen E.
Marcelo Cynthia L.
Roessler Blake J.
Azpuru Carlos A
Kamp James F.
Rader & Fishman & Grauer, PLLC
The Regents of the University of Michigan
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