Mucosal adhesive device for long-acting delivery of pharmaceutic

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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424434, 424464, 424465, A61K 920

Patent

active

055783155

ABSTRACT:
Mucosal adhesive devices are provided for use in the oral cavity for therapy against infections. The devices are dosage units which comprise a combination of antimicrobial agents such as antifungal agents and anti-inflammatory agents, optionally also a local anesthetic. The dosage units yield a gradual and relatively constant release of the pharmaceuticals over at least a 12-hour period.

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WO89/10740, Innovata Biomed Ltd, "Buccal Local Anaesthetic", Published Nov. 16, 1989.
WO92/00725, Farcon AG, "Liquid Oral Pharmaceutical Compositions Having Anti-Inflamatory Activity", Published Jan. 23, 1992.
WO92/17167, Biotech Australia, "Oral Delivery Systems For Microparticles", Published Oct. 15, 1992.
Drug Development And Industrial Pharmacy, 19(14), 1755-1808, 1993 "A New Transmucosal Therapeutic System:Overview Of Formulation Development And In-Vitro/In-Vivo Clinical Performance", Y. Nozaki, et al.
Eur J Clin Pharmacol (1992) 43: 137-140, "Comparison of Salivary Miconazole Concentrations After Adminstration of A Bioadhesive Slow-Release Buccal Tablet And An Oral Gel", S. Bouckaert, et al.
Journal of Pharmaceutical Sciences, vol. 79, No. 2, Feb. 1990, "Bioadhesive Lozenge For The Improved Delivery of Cetylpyridinium Chloride", Augusta Collins, et al.
Journal of Controlled Release, 6(1987) 353-360, "Buccal/Gingival Drug Delivery Systems", Nagal.

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