Mucopolysaccharide composition having a regulatory action on coa

Details Mucopolysaccharide composition having a regulatory action on coa Mucopolysaccharide composition having a regulatory action on coa

1981-09-14

1984-12-04

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated to proteinaceous toxin or fragment thereof

536 21, A61K 31727, C08B 3710

Patent

active

044864205

ABSTRACT:
The invention pertains to a mucopolysaccharide fraction obtainable from heparin or from fractions including heparinic constituents of molecular weights from 2,000 to 50,000, which has a Yin-Wessler titer which is high relative to the USP titer. It contains components whose molecular weights are less than 10,000, particularly oligosaccharides in the area of 2,000-3,000, comprising from 8 to 12, notably 10 monosaccharide units, among which glucosamine units whose primary positions are sulphated. The last mentioned oligosaccharides include one N-acetyl-glucosamine unit per two units of 2-0-sulphate iduronic acid and per two N-sulphate-glucosamine units, the other saccharide units being of a different nature and including distinct substituents.

REFERENCES:
patent: 4168377 (1979-09-01), Choay et al.
patent: 4175182 (1979-11-01), Schmer
patent: 4281108 (1981-07-01), Fussi
patent: 4303651 (1981-12-01), Lindahl et al.
patent: 4315923 (1982-02-01), Takacs et al.

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