Mucoadhesive compositions for administration of biologically act

Details Mucoadhesive compositions for administration of biologically act Mucoadhesive compositions for administration of biologically act

1998-05-12

1999-08-24

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424435, A61K 4732, A61K 902

Patent

active

059422432

ABSTRACT:
This invention pertains to mucoadhesive compositions for the delivery of pharmacologically active agents, and to polymeric formulations that allow for a prolonged, sustained release of the active agents. More specically the invention pertains to compositions for the delivery of drugs to mucosal tissue, said composition comprising a drug or a plurality of drugs to be delivered and a thermoplastic graft copolymer, said graft copolymer being the reaction product of a polystyrene macromonomer having an ethylenically unsaturated functional group, and at least one acidic hydrophilic monomer having an ethylenically unsaturated functional group.

REFERENCES:
patent: 3598122 (1971-08-01), Zaffaroni
patent: 4994322 (1991-02-01), Delgado et al.
patent: 5104952 (1992-04-01), Babu
patent: 5116910 (1992-05-01), Tone et al.
patent: 5179158 (1993-01-01), Azuma et al.
patent: 5417983 (1995-05-01), Nagase et al.
E. Arca et al. Release of . . . Media Int.J. Pol. Anal.--Character. 1995 vol.2, pp. 31-41 Nov. 1994.

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