Mucoadhesive carrier for delivery of therapeutical agent

Details Mucoadhesive carrier for delivery of therapeutical agent Mucoadhesive carrier for delivery of therapeutical agent

1988-06-03

1991-09-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424434, 424443, 424448, 424484, 424486, 424 78, A61F 1300, A61K 926

Patent

active

050472445

ABSTRACT:
A mucoadhesive carried suitable for a therapeutic agent is disclosed. This carrier allows controlled release of the therapeutic agent via mucosal tissue. The mucoadhesive carrier comprises a Monolithic polymer matrix that is anhydrous but hydratable, and amorphous fumed silica. The silica enhances the mucoadhesive properties of the carrier. An optional water-insoluble barrier film or layer can be secured to the polymer matrix to provide a non-adhering face.

REFERENCES:
patent: 3551556 (1970-12-01), Kliment et al.
patent: 3911099 (1975-10-01), DeFoney et al.
patent: 4704119 (1987-11-01), Shaw et al.
patent: 4740365 (1928-04-01), Yukimatsu et al.

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