Mu opioid receptor ligands: methods of use and synthesis

Details Mu opioid receptor ligands: methods of use and synthesis Mu opioid receptor ligands: methods of use and synthesis

2007-05-29

2007-05-29

Page, Thurman K. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S161000, C564S170000, C564S171000, C564S174000

Reexamination Certificate

active

10683756

ABSTRACT:
Novel compounds and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are useful in therapeutic applications, including modulation of disease or disease symptoms in a subject (e.g., mammal, human, dog, cat, horse). The compounds are useful as modulators of the mu opioid receptor (MOR) through their binding affinity with that receptor.

REFERENCES:
patent: WO 99/65932 (1999-12-01), None
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Harrison et al., “High-Affinity Mu Opioid Receptor Ligands Discovered by the Screening of an Exhaustively Stereodiversified Library of 1, 5-Enediols”, 2002, J. Am. Chem. Soc., vol. 124;13352-13353.
Harrison et al., “2, 6-Dimethyltyrosine Analogues of a Stereodiversified Ligand Library: Highly Potent, Selective, Non-Pepticμ Opioid Receptor Agonists”, 2003, J. Med. Chem., vol. 46;677-680.
Gierasch et al., “A Modular Synthetic Approach toward Exhaustively Stereodiversified Ligand Libraries”, 2000, Organic Letters, vol. 2 (25);3999-4002.
International Search Report for PCT/US03/32280; mailed Dec. 3, 2004.

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