Mu-opiate receptor peptides

Details Mu-opiate receptor peptides Mu-opiate receptor peptides

1997-03-25

1999-03-23

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 514 18, 435 71, 436 86, 436501, A61K 3812, C07K 512

Patent

active

058859586

ABSTRACT:
This invention relates to certain peptides and linear and cyclic analogs thereof that bind to the mu (morphine) opiate receptor with higher affinity, selectivity and potency than currently available peptides. This invention also relates to pharmaceutical preparations containing an effective amount of the peptides or salts thereof, and methods for providing analgesia, relief from gastrointestinal disorders such as diarrhea, and therapy for drug dependence containing a pharmaceutically effective amount of the peptides.

REFERENCES:
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patent: 5455230 (1995-10-01), Schiller
Sakaguchi et al., Bull. Chem. Soc. JPN 65 No. 4 1052-1056 (1992).
Schiller, et al., Proc. Natl. Acad. Sci. USA. 89:11871-11875 (1992).
Schiller, et al., J. Med. Chem. 32:698-703 (1989).
Dooley, et al., Peptide Res. 8:124-137 (1995).
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Zadina, et al., Peptides. 15:1567-1569 (1994).
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Zadina et al., Nature 38613:499-502 (1997).
Schiller et al., Journal of Medicinal Chemistry 32:698-703 (1989).
Sakaguchi et al., Bull. Chem. Soc. Jpn. 65:1052-1056 (1992).
Schiller et al., Advances in the Biosciences 75:85-88 (1989).

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