Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1995-06-07
1998-04-14
Ketter, James
Chemistry: molecular biology and microbiology
Spore forming or isolating process
43525233, 4353201, 536 2431, 536 2433, 536 231, C12N 1585
Patent
active
057390274
ABSTRACT:
The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
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Ketter James
Myriad Genetics Inc.
Yucel Iren
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