MTS1 gene mutations

Details MTS1 gene mutations MTS1 gene mutations

1998-07-22

2000-03-14

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 4352523, 4353201, C07H 2104, C12N 121, C12N 1563

Patent

active

060374624

ABSTRACT:
The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

REFERENCES:
patent: 5801236 (1998-09-01), Kamb
Embl-est58, Aug. 16, 1999.
Patent-issued, Aug. 16, 1999.
Patent-pending
Geneseq35, Aug. 16, 1999.

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