mTOR kinase-associated proteins

Details mTOR kinase-associated proteins mTOR kinase-associated proteins

2006-05-30

2006-05-30

Carlson, Karen Cochrane (Department: 1653)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

Reexamination Certificate

active

07052870

ABSTRACT:
The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.

REFERENCES:
Ohara et al., Characterization of Size-Fractionated cDNA Libraries Generated by the in vitro Recombination-Assited Method, DNA Research, (2002), 9, p. 47-57.
GenCore version 5.1.6 search for the SEQ ID No.: 2. (p. 1, 17-19).
GenCore version 5.1.6 search for the SEQ ID No.: 3. (p. 1, 5, and 6).
Chen, J., et al., “Identification of an 11-kDa FKBP 12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin associated protein and characterization of a critical serine residue,” Proc. Natl. Acad. Sci. USA, 92:4947-4951 (1995).
Dennis, P.B., et al., “Mammalian TOR: A Homeostatic ATP Sensor,” Science, 294:1102-1105 (2001).
Gao, X., et al., “Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling,” Nature Cell Biology, 4:699-704 (2002).
Hara, K., et al., “Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action,” Cell, 110:177-189 (2002).
Hentges, K.E., et al., “FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse,” PNAS, 98(24):13796-13801 (2001).
Keith, C.T. and Schreiber, S.L., Science 270 (5233): 50-1 (abstract).
Kim, D-H., et al., “GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR,” Molecular Cell, 11:895-904 (2003).
Kim, D-H., et al., “mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery,” Cell, 110(2):163-175 (2002).
Kwiatkowski, D.J., et al., “A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells,” Human Molecular Genetics, 11(5):525-534 (2002).
Liu, Z., et al., “RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p,” The EMBO Journal, 20(24):7209-7219 (2001).
Mammalian Gene Collection (MGC) Program Team: “Generation and Initial Analysis of More Than 15,000 Full-Length Human and Mouse cDNA Sequences”, Proceedings of the National Academy of Sciences of USA, National Academy of Science, 99(26): 16899-16903 (2002).
Neshat, M.S., et al., “Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR,” PNAS, 98(18):10314-10319 (2001).
Nojima, H., et al., “The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p. 70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif,” Journal of Biological Chemistry, 278(18):15461-15464 (2003).
Ochotorena, I.L., et al., “Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturation,” Journal of Cell Science, 114:2911-2920 (2001).
Podsypanina, K., et al., “An inhibitor of mTOR reduces neoplasia and normalizes p. 70/S6 kinase activity in Pten+/− mice,” PNAS, 98(18):10320-10325 (2001).
Riken Genome Exploration Research Group Phase II Team and Fantom Consortium: “Functional Annotation of a Full-Length Mouse CDNA Collection”, Nature, MacMillan Journals Ltd., London, GB, 409(6821): 685-690 (2001).
Roberg, K.J., et al., “Control of Amino Acid Permease Sorting in the Late Secretory Pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8,” Genetics, 147:1569-1584 (1997).
Rodgers, B.D., et al, “Insulin regulation of a novel WD-40 repeat protein in adipocytes,” Journal of Endocrinology, 168:325-332 (2001).
Sabatini, D.M., et al., “RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs,” Cell, 78(1):35-43 (1994) abstract.
Sarbassov, Dos D., et al., “Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton”, Current Biology, 14: 1296-1302 (2004).
Schmeizie, T., et al., “TOR, a Central Controller of Cell Growth,” Cell, 103:253-262 (2000).
Vogt, P.K., “PI 3-kinase, mTOR, protein synthesis and cancer,” Trends in Molecular Medicine, 7(11):482-484 (2001).

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