Mst1 modulation of apoptosis in cardiac tissue and...

Details Mst1 modulation of apoptosis in cardiac tissue and... Mst1 modulation of apoptosis in cardiac tissue and...

2007-01-09

2007-01-09

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000, C435S007100

Reexamination Certificate

active

10683576

ABSTRACT:
The present invention relates to methods and agents for treatment, amelioration and prevention of cardiac disease, including cardiac myopathy, chronic heart failure and for management and reduction of cardiac myocyte death which may occur in response to ischemia/reperfusion or following myocardial infarction or other injury to the heart. The invention relates to methods for screening cardiotherapeutic compounds, including compounds which modulate cardiac myocyte apoptosis, particularly targeting Mst1 and the Mst1 pathway. The present invention further encompasses compounds identified by such screening methods and compositions comprising these compounds. The invention also provides methods for treatment, amelioration and prevention of cardiac disease comprising administering compounds or agents which modulate, particularly inhibit, Mst1 or the Mst1 kinase pathway, including administering a nucleic acid encoding an altered form of Mst1, particularly a dominant negative Mst1, which acts as an antagonist of Mst1.

REFERENCES:
patent: 4975444 (1990-12-01), Danilewicz et al.
patent: 6225288 (2001-05-01), Han et al.
patent: 2003/0130216 (2003-07-01), Laugwitz et al.
patent: 2004/0009957 (2004-01-01), Kukreja
Yamamoto et al, Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes, J Mol Cell Cardiol. Oct. 2001;33(10):1829-48.

Affiliated with

Also associated with

Rating

Mst1 modulation of apoptosis in cardiac tissue and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mst1 modulation of apoptosis in cardiac tissue and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mst1 modulation of apoptosis in cardiac tissue and... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3771192