MSP-18 protein and nucleic acid molecules and uses therefor

Details MSP-18 protein and nucleic acid molecules and uses therefor MSP-18 protein and nucleic acid molecules and uses therefor

1999-03-25

2000-10-31

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4353201, 435325, 4352523, 435 691, 536 231, C12Q 168, C12P 2106, C12N 120, C12N 1500, C07H 2102

Patent

active

061400564

ABSTRACT:
Novel MSP-18 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length MSP-18 proteins, the invention further provides isolated MSP-18 fusion proteins, antigenic peptides and anti-MSP-18 antibodies. The invention also provides MSP-18 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a MSP-18 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
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Copy of Blast.TM. Search using Non-redundant database of nucleic acid sequence using MSP-18 Nucleic Acid Sequences.
Copy of Blast.TM. Non-redundant database of nucleic acid sequences using MSP-18 coding sequences.
Copy of Blast.TM. Search of Non-redundant GenBank.TM. database of protein sequences using MSP-18 Amino Acid Sequences.
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GenBank.RTM. Accession Number AA269410 for Soares mouse 3NME12 5 Mus musculus cDNA clone Image:734001 5' similar to SW:LYOX.sub.-- Human P28300 Protein-Lysine 6-Oxidase Precursor; Mar. 26, 1997.
GenBank.RTM. Accession Number AA369741 for Pancreas tumor II Homo sapiens cDNA 5" end; Apr. 21, 1997.
GenBank.RTM. Accession Number AA522066 for Barstead mouse myotubes MPLRB5 Mus musculus cDNA clone IMAGE:903231 5' similar to SW:WC11.sub.-- Bovin P30205 Antigen WC1.1; Jul. 17, 1997.
GenBank.RTM. Accession Number AA530866 for NCI.sub.-- CGAP.sub.-- Pr21 Homo sapiens cDNA clone Image:984748 3'; Aug. 20, 1997.
GenBank.RTM. Accession Number AA625414 for Soares.sub.-- NhHMPu.sub.-- S1 Homo sapiens cDNA clone Image:1047259 af69b10.r1 Soares.sub.-- NhHMPu.sub.-- S1 Homo sapiens cDNA clone Image:1047259 5'; Mar. 2, 1998.
GenBank.RTM. Accession Number AA673141 for Soares mouse mammary gland NbMMG Mus musculus cDNA clone IMAGE:820637 5' similar to SW:LYOX.sub.-- RAT P16636 Protein-lysine 6-Oxidase Precursor; Nov. 26, 1997.
GenBank.RTM. Accession Number for AA792234 for Soares mouse mammary gland NbMMG Mus musculus cDNA clone Image:820612 5' similar to gb:M65142 Mouse lysyl oxidase mRNA, complete cds (Mouse); Feb. 9, 1998.
GenBank.RTM. Accession Number AA852888 for normal Human Trabecular Bone Cells Homo sapiens cDNA clone NHTBCae01a08; May 12, 1999.
GenBank.RTM. Accession Number AA852889 for normal Human Trabecular Bone Cells Homo sapiens cDNA clone NHTBCae01a08; May 12, 1999.
GenBank.RTM. Accession Number AI082055 for Soares.sub.-- senescent.sub.-- fibroblasts.sub.-- NbHSF Homo sapiens cDNA clone Image:1678980 3' similar to TR:Q08397 Q08397 Protein-Lysine Oxidase Homolog Precursor; contains TAR1.t1 MSR1 repetitive element; Oct. 1, 1998.
GenBank.RTM. Accession Number AI148499 for Soares.sub.-- placenta.sub.-- 8to9weeks.sub.-- 2NbHP8to9W Homo sapiens cDNA clone Image:171462 3'; Oct. 27, 1998.
GenBank.RTM. Accession Number AI180353 for normalized rat spleen, Bento Soares Rattus sp. CDNA clone RSPCV22 3' end; Jan. 20, 1999.
GenBank.RTM. Accession Number AAI249780 for NCI.sub.-- CGAP.sub.-- Pan1 Homo sapiens cDNA clone Image:2004863 3' similar to TR:Q60997 Q60997 CRP-Ductin Precursor; contains TAR1.t1 TAR1 repetitive element; Feb. 3, 1999.
GenBank.RTM. Accession Number AI251754 for Soares.sub.-- NFL.sub.-- T.sub.-- GBC.sub.-- S1 Homo sapiens cDNA clone Image:1854302 3'; Jan. 27, 1999.
GenBank.RTM. Accession Number AI262314 for NCI.sub.-- CGAP.sub.-- Co8 Homo sapiens cDNA clone Image:1870845 3'; Jan. 28, 1999.
GenBank.RTM. Accession Number AI291580 for Soares.sub.-- placenta.sub.-- 8to9weeks.sub.-- 2NbHP8to9W Homo sapiens cDNA clone Image:1894465 3'; Nov. 30, 1998.
GenBank.RTM. Accession Number AI291685 for Soares.sub.-- placenta.sub.-- 8to9weeks.sub.-- 2NbHP8to9W Homo sapiens cDNA clone Image:1894522 3'; Jan. 29, 1999.
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GenBank.RTM. Accession Number AC003061 for Mouse chromosome 6 BAC Clone b245c12, complete sequence; Dec. 8, 1998.
GenBank.RTM. Accession Number AC005033 for Homo sapiens clone NH0140K04, complete sequence; Jan. 14, 1999.
GenBank.RTM. Accession Number AC005041 for Homo sapiens clone NH0523H20, complete sequence; Mar. 24, 1999.
GenBank.RTM. Accession Number AF053368 for Mus musculus lysyl oxidase-related protein 2 (Lor2) mRNA, complete cds. Mar. 15, 1999.
GenBank.RTM. Accession Number AF084363 for Mus musculus D6MM5e protein (D6Mm5e) and DOK protein (Dok) genes, complete cds; and LOR2 protein (Lor2) gene, partial cds; Mar. 15, 1999.
GenBank.RTM. Accession Number AF103901 for Perca flavescens lysyl oxidase homolog (PLO1) mRNA, partial cds; Apr. 14, 1999.
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GenBank.RTM. Accession Number OXHUL for protein-lysine 6-oxidase (EC 1.4.3.13) precursor--human; Sep. 6, 1996.
GenBank.RTM. Accession Number P21757 for macrophage scavenger receptor types I and II (macrophage acetylated LDL receptor I and II); Jul. 15, 1998.

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