MSH2 disrupted mice develop lymphomas

Details MSH2 disrupted mice develop lymphomas MSH2 disrupted mice develop lymphomas

1996-01-18

1999-05-25

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 424 91, 435354, C12N 500, C12N 1500, A61K 4900

Patent

active

059070790

ABSTRACT:
Non-human mammals comprising a disrupted MSH2 gene are disclosed. More particularly, animals having a disruption in one or both alleles of the MSH2 gene or a homolog of the MSH2 gene are disclosed. Animals homozygous for the disruption are viable past the embryonic stage of development but show an increased incidence of lymphoma, intestinal adenomas and carcinomas, and squamous cell tumors of the skin. Specifically disclosed are mice whose genome comprises a disrupted MSH2 gene such that the mice exhibits an increase in the incidence of spontaneous lymphoma over the incidence of spontaneous lymphoma in wild type mice.

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