MS/MS time-of-flight mass-spectrometer with collision cell

Radiant energy – Ionic separation or analysis – Ion beam pulsing means with detector synchronizing means

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

H01J 4940

Patent

active

058544852

ABSTRACT:
In order to effect fragmentation of ions through collisions with gas-phase molecules, it is necessary to have a high gas pressure in the collision region. At the same time the residual gas pressure in the detector region of a mass-spectrometer must be kept low. This is done by arranging collision cell and detector into separately pumped vacuum regions, each region having its own pumping port, the regions only being connected via flow restrictions in the vicinity of the ion optical axis. Achieving large pressure gradients and at the same time not reducing the sensitivity of the mass spectrometer can be done by using gas flow restrictions with large cross sections. A very efficient and space saving arrangment is to place a separate chamber with the collision cell between the chamber housing the reflector and the detector and the chamber housing the ion source of the mass spectrometer.

REFERENCES:
patent: 3621240 (1971-11-01), Cohen
patent: 5032722 (1991-07-01), Boesle et al.
patent: 5202563 (1993-04-01), Cotter et al.
D.J. Beussman et al. "Tandem Reflection Time-of-Flight Mass Spectrometer Utilizing Photodissociation" Analytical Chemistry, 1995, pp. 3952-3957, vol. 67 (21) American Chemical Society.
B. Spengler et al: "Fundamental Aspects of Postsource Decay in Matrix-Assisted Laser Desorption Mass-Spectrometry: 1 Residual Gas Effects" Journal of Physical Chemistry, 1992, pp. 9678-9684 vol. 96 American Chemical Society.
T. J. Cornish et al: "A Curved field Reflection for Improved Energy Focusing of Product Ions in Time-of-Flight Mass Spectrometry" Rapid Communications in Mass Spectrometry, 1993, pp. 1037-1040, vol. 7, John Wiley & Sons.
T. J. Cornish et al: "Tandem Time-of-Flight Mass Spectrometer" Analytical Chemistry, 1993, pp. 1043-1047, vol. 65 American Chemical Society.
R. D. Beck et al: "Tandem time-of-flight mass spectrometer for cluster-surface scattering experiments" Review of Scientific Instruments of Physics.
H. Haberland et al: "Converting a reflection time-of-flight mass spectrometer into a tandem instrument" Review of Scientific Instruments, 1991, pp. 2368-2371, vol. 62, American Institute of Physics.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

MS/MS time-of-flight mass-spectrometer with collision cell does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with MS/MS time-of-flight mass-spectrometer with collision cell, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MS/MS time-of-flight mass-spectrometer with collision cell will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1426571

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.