MRP-related ABC transporter encoding nucleic acids and...

Details MRP-related ABC transporter encoding nucleic acids and... MRP-related ABC transporter encoding nucleic acids and...

2007-12-25

2007-12-25

Chen, Shin-Lin (Department: 1632)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S320100, C435S325000, C435S455000, C536S023100, C536S023500, C424S093210

Reexamination Certificate

active

10889503

ABSTRACT:
Novel human MOAT genes and their encoded proteins are provided herein. The MRP-related ABC transporters encoded by the disclosed nucleic acid sequences play a pivotal role in the efflux of pharmacologically beneficial reagents from tumor cells. MOAT genes and their encoded proteins provide valuable therapeutic targets for the design of anti-cancer agents which inhibit the aberrant growth of malignant cells.

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