MRI method for high liver iron measurement using magnetic suscep

Details MRI method for high liver iron measurement using magnetic suscep MRI method for high liver iron measurement using magnetic suscep

1991-07-22

1993-08-10

Jaworski, Francis

Surgery

Truss

Pad

1286535, 324308, 324321, A61B 5055

Patent

active

052339920

ABSTRACT:
A subject (22), such as a human patient, is positioned with a region of interest (24), such as the liver, close proximity to a phantom (12). A Volume image through the liver, the phantom, and adjacent portions of the subject are collected (40) with a magnetic resonance scanner. The phase component of the magnetic resonance data is reconstructed (50) into a three-dimensional phase map. An actually measured field map H.sub.m (r) is determined (42) from the phase map. A geometric model of the volumes occupied by the liver, the phantom, and adjacent portions of the subject are defined mathematically (44). A calculation routine (46) calculates a calculated or estimated field map H.sub.c (r) of the distortions to the magnetic field in the phantom which would be caused by the model. A least squares fit routine (48) (i) compares the calculated field map and the measured field map, (ii) based on the difference adjusts a susceptibility of material in the region of interest as defined in the model, and (iii) recalculates the field map. This fitting procedure is iteratively repeated until a susceptibility is determined for the region of interest which predicts the actually measured field map. This susceptibility is proportional to iron concentration.

REFERENCES:
patent: 4849210 (1989-07-01), Widder
patent: 5055791 (1991-08-01), Le Roux et al.
patent: 5071602 (1991-12-01), Nambu et al.

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