Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1993-07-22
1995-01-10
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 1286534, 534 15, 540465, 540474, 514184, 514836, A61B 5055
Patent
active
053805151
ABSTRACT:
Polyphosphonate ligands containing three or more phosphonate groups, combined with paramagnetic metal cations and administered in the form of pharmacologically acceptable salts, are useful as MRI contrast enhancement agents, which tend to localize in bone tissue without being conjugated to bone-specific biomolecules. Triazacyclononanes and tetraazacyclododecanes, with dihydroxyphosphorylmethyl or dihydroxyphosphorylethyl groups, optionally substituted at the methyl or ethyl bridges with alkyl, aryl, hydroxyl or amino groups, are particularly preferred.
REFERENCES:
patent: 4647447 (1987-03-01), Gries et al.
Kabachnik, M. I., Chem. Abs. 101(21):192203s. From: Otkrytiya Izobret. Prom. Obraztsy, Tovarnye Znaki, 23:84-85 (1984).
Cyjon Rosa L.
Klein Joseph Y.
Klein Ofer
Simhon Elliot D.
Winchell Harry S.
Concat, Ltd.
Hollinden Gary E.
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