MRI image enchancement of bone and related tissue using complexe

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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514184, 514 36, 534 15, 540465, A61B 5055

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active

055936598

ABSTRACT:
Polyphosphonate ligands containing three or more phosphonate groups, combined with paramagnetic metal cations and administered in the form of pharmacologically acceptable salts, are useful as MRI contrast enhancement agents, which tend to localize in bone tissue without being conjugated to bone-specific biomolecules. Triazacyclononanes and tetraazacyclododecanes, with dihydroxyphosphorylmethyl or dihydroxyphosphorylethyl groups, optionally substituted at the methyl or ethyl bridges with alkyl, aryl, hydroxyl or amino groups, are particularly preferred.

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Geraldes et al., Inorganic Chemistry, 28:3336-3341 (1989).
Kabachnik et al., Izv. Akad. Nauk SSr, Ser. Khim., 4:844-849 (1984).

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