MRI contrast agents

Details MRI contrast agents MRI contrast agents

2008-05-06

2008-05-06

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

C424S009100, C424S009300

Reexamination Certificate

active

10546964

ABSTRACT:
An MRI contrast agent enables direct detection and imaging of exfoliated vascular endothelial sites. The MRI contrast agent includes an imaging unit which contains an unpaired electron-carrying atom and/or molecule and is capable of amplifying or reducing MRI signals, and a detection unit which is bonded to the imaging unit and is capable of selectively recognizing exfoliated vascular endothelial sites and binding thereto. The detection unit is exemplified by one having a chemical structure expressed by the following formula (I), wherein at least one of R1-R11is, for example, a sulfonic acid group, and X is, for example, a phenyl group which may be substituted:

REFERENCES:
patent: 2004/0204344 (2004-10-01), Huang
patent: WO0074727 (2000-12-01), None
Yamamoto et al. (Analytical Sciences 2004, 20, 5-7).
Dezutter et al. (Nucl. Med. Comm. 2001, 22, 553-558).

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