MRE11 orthologue and uses thereof

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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Details

C435S440000, C435S252300, C435S320100, C435S069100, C435S071100, C536S023200, C536S023600

Reexamination Certificate

active

07060480

ABSTRACT:
The invention provides isolated Mre11 nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering Mre11 levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions.

REFERENCES:
patent: 5500365 (1996-03-01), Fischhoff et al.
patent: WO 97/08331 (1997-03-01), None
patent: WO 99/37789 (1999-07-01), None
patent: WO 99/41394 (1999-08-01), None
patent: WO 00/12716 (2000-03-01), None
patent: WO 00/15816 (2000-03-01), None
patent: WO 00/42205 (2000-07-01), None
Sequence Alignment—Seq Id No.:2 and T52564.
Chamankhah et al., Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions, Gene 225:107-116 (1998).
Tavassoli et al., Cloning and characterisation of theSchizosaccharomyces pomberad32 gene: a gen required for repair of double strand breaks and recombination, Nucleic Acids Res. 23(3):383-388 (1995).
Usui et al., Complex Formation and Functional Versatility of Mre11 Budding Yeast in Recombination, Cell 95:705-716 (1998).
Lee et al.,SaccharomycesKu70, Mre11/Rad50 and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage, Cell 94:399-409 (1998).
Carney et al., The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response: Cell 93:477-486 (1998).
Tsukamoto et al., Effects of Mutations of RAD50, RAD51, RAD52, and Related Genes on Illegitimate Recombination inSaccharomyces cerevisiae, Genetics 142:383-391 (1996).
Paull et al., The 3′ to 5′ Exonuclease Activity of Mre11 Facilities Repair of DNA Double-Strand Breaks, Molecular Cell 1:969-979 (1998).
Trujillo et al., Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95, J. Biol. Chem. 273(34):21447-21450 (1998).
Ajimura et al., Identification of New Genes Required for Meiotic Recombination inSaccharomyces cerevisiae, Genetics 133:t51-66 (1993).
Johzuka et al., Interaction of Mre11 and Rad50: Two Proteins Required for DNA Repair and Meiosis-Specific Double-Strand Break Formation inSaccharomyces cerevisiae, Genetics 139:1521-1532 (1995).
Petrini et al., Isolation and Characterization of the Human MRE11 Homologue, Genomics 29:80-86 (1995).
Furuse et al., District roles of two seperable in vitro activities of yease Mre11 in mitotic and meiotic recombination, EMBO Journal 17(21):6412-6425 (1998).
Xiao et al., Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells, Nucleic Acids Res. 25(15):2985-2991 (1997).
Yamaguchi-Iwai et al., Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells, EMBO Journal 18(23):6619-6629 (1999).
Wilson et al., the role ofSchizosaccharomyces pombeRad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance, Nucleic Acids Res. 27(13):2655-2661 (1999).
Dolganov et al., Human Rad50 is Physically Associated with Human Mre11:Identification of a conserved Multiprotein Complex Implicated in Recombinational DNA Repair, Mol. Cell. Biol. 16(9):4832-4841 (1996).
Lewis et al., Repair of Endonuclease-Induced Double-Strand Breaks inSaccharomyces cerevisiae: Essential Role for Genes Associated with Nonhomologous End-Joining, Genetics 152:1513-1539 (1999).
Moore et al., Cell Cycle and Genetic Requirements of Two Pathways of Nonhomologous End-Joining Repair of Double-Strand Breaks inSaccharomyces cerevisiae, Mol. Cell Biol. 16(5):2164-2173 (1996).
Nairz et al., mre11S-yeast mutation that blocks double-stand-break processing and permits nonhomologous synapsis in meiosis, Genes & Development 11:2272-2290 (1997).
Tsubouchi et al., A Novel mre11 Mutation Impairs Processing of Double-Strand Breaks of DNA during Both Mitosis and Meiosis, Mol. Cell. Biol. 18(1):260-268 (1998).
Hartung et al., Accession No. Q9XGM2,Arabidopsis thaliana(Mouse-ear cress), (1999).
Hartung et al., Accession No. AJ243822,Arabidopsis thalianamRNA for Mre11 protein (MRE11 gene), (1999).
Gerecke et al., Accession No. AF178433,Coprinus cinereusDNA repair and Meiosis protein Mre11 (mre11) gene, complete cds (1999).
Bibikova et al., Accession No. AF134569,Xenopus laevisputative nuclease Mre11 (MRE11) mRNA, complete cds (1999).
Brodsky et al., Accession No. AF132144,Drosophila melanogasterclone LD8638 endo/exonuclease Mre11 (mre11) mRNA, complete cds (1999).
Hartung et al., Isolation of the Complete cDNA of the Mre11 Homologue ofArabidopsis(Accession No. AJ243822) Indicated Conservation of DNA Recombination Mechanisms Between Plants and Other Eucaryotes, Plant Gene Register PGR99-132 Plant Physiol. 121:132 (1999).
Nakamura, Y., EMBL Accession No. AB010695,Arabidopsis thalianagenomic DNA, chromosome 5, P1 clone:MDK 4 (1998).
Jaesung et al., Accession No. PREV199800510932,Agrobacterium tumefacienstransformation of thethalianamutants uvh1 and rad5 (1998).
Nam et al.,Agrobacterium turnefaciensTransformation of the Radiation HypersensitiveArabidopsis thalianaMutants uvh1 and rad5, MPMI 11(11):1136-1141 (1998).
Mysore et al., An arabidopsis histone H2A mutant is deficient in Agrobacterim T-DNA integration, PNAS 97(2):948-953 (2000).
Lewin, B., Most eukaryotic mRNAs are polyadenylated at the 3′ end, Genes V 10:264-165 (1994), Oxford University Press, New York.
Doerks, T., Protein annotation: detective work for function prediction, TIG 14(6):248-250 (1998).
Smith et al., The challenges of genome sequence annotation or “The devil is in the details”, Nature Biotechnology 15:1222-1223 (1997).
Brenner, S.E., Errors is genome annotation, TIG 15(4):132-133 (1999).
Bork et al., Go hunting in sequence databases but watch out for the traps, TIG 12(10):425-427 (1996).
Van De Loo et al., An oleate 12-hydroxylase fromRicinus communis L, is a fatty acyl desatruase homolog, Proc. Natl. Acad, Sci. USA 92:6743-6747 (1995).

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