MRE 11: modulation of cellular proliferation

Details MRE 11: modulation of cellular proliferation MRE 11: modulation of cellular proliferation

2008-04-15

2008-04-15

Vogel, Nancy (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Reexamination Certificate

active

10026331

ABSTRACT:
The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding MRE11, which is a protein involved in modulation of cellular proliferation. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, and ribozymes, that modulate cellular proliferation via modulation of MRE11; as well as to the use of expression profiles and compositions in diagnosis and therapy related to modulation of cellular proliferation.

REFERENCES:
patent: 2002/0115057 (2002-08-01), Young
patent: 2002/0182586 (2002-12-01), Morris et al.
de Jager et al. Nuc. Acids Res. 2001; 29:1317-25.
Furuse et al. EMBO J. 1998.
Lanson et al. Nuc. Acids Res. 2000; 28:2882-92.
Moreau et al. Mol. Cell. Biol. 1999; 19:556-566.
Paull et al. Genes Dev. 1999; 13:1276-88.
Petrini, Am. J. Hum. Genet. 1999; 64:1264-69.
Fukuda, T. et al. “Alterations of the Double-strand Break Repair Gene MRE11 in Cancer,”Cancer Res., Jan. 1, 2001, pp. 23-26, vol. 61.
Hopfner, K. et al. “Structural Biochemistry and Interaction Architecture of the DNA Double-strand Break Repair MRE11 Nuclease and RAD50-ATPase,”Cell, May 18, 2001, pp. 473-485, vol. 105.
Kim, K. K. et al. “Mouse RAD50 has Limited Epitopic Homology to p53 and is Expressed in the Adult Myocardium,”J. Biol., Chem.Nov. 15, 1996, pp. 29255-29264, vol. 271, No. 46.
Lombard, D. B. and Guarente, L. “Nijmegen Breakage Syndrome Disease Protein and MRE11 at PML Nuclear Bodies and Meiotic Telomeres,”Cancer Res., May 1, 2000, pp. 2331-2334, vol. 60.
Paull, T. T. and Gellert, M. “The 3' to 5' Exonuclease Activity of MRE11 Facilities Repair of DNA Double-strand Breaks,”Molecular Cell, Jun. 1998, pp. 969-979, vol. 1.
Petrini, J. H. L. “DNA Repair '99: The Mammalian MRE11-RAD50-NBS1 Protein Complex: Integration of Functions in the Cellular DNA-Damage Response,”Am. J. Hum. Genet., 1999, pp. 1264-1269, vol. 64.
Stewart, G. S. et al. “The DNA Double-Strand Break Repair Gene hMRE11 is Mutated in Individuals with an Ataxia-Telangiectasia-like Order,”Cell, Dec. 10, 1999, pp. 577-587, vol. 99.

Affiliated with

Also associated with

Rating

MRE 11: modulation of cellular proliferation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with MRE 11: modulation of cellular proliferation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MRE 11: modulation of cellular proliferation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3952341