MR-method for the in vivo measurement of temperature or...

Details MR-method for the in vivo measurement of temperature or... MR-method for the in vivo measurement of temperature or...

2007-07-31

2007-07-31

Casler, Brian L. (Department: 3737)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

C600S407000, C600S412000, C600S420000, C600S431000, C324S307000, C324S309000

Reexamination Certificate

active

10240754

ABSTRACT:
The present invention provides a method of MR investigation of a sample, said method comprising: (i) nuclear spin polarizing a high T1 MR imaging agent which contains in its molecular structure at least two hyperpolarisable nuclei within the same molecule, the frequency difference between the two resonance lines from said nuclei, δυ, being dependent upon either the temperature or the pH of said sample; (ii) administering the nuclear spin polarized MR imaging agent to said sample; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in said MR imaging agent; and (iv) detecting and manipulating magnetic resonance signals from said sample using a single-shot RARE acquisition sequence with shifted data acquisition.

REFERENCES:
patent: 6453188 (2002-09-01), Ardenkjaer-Larsen et al.
patent: 6574495 (2003-06-01), Golman et al.

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